Detection of CWD prions in naturally infected white-tailed deer fetuses and gestational tissues by PMCA.
Sci Rep
; 11(1): 18385, 2021 09 15.
Article
en En
| MEDLINE
| ID: mdl-34526562
ABSTRACT
Chronic wasting disease (CWD) is a prevalent prion disease affecting cervids. CWD is thought to be transmitted through direct animal contact or by indirect exposure to contaminated environmental fomites. Other mechanisms of propagation such as vertical and maternal transmissions have also been suggested using naturally and experimentally infected animals. Here, we describe the detection of CWD prions in naturally-infected, farmed white-tailed deer (WTD) fetal tissues using the Protein Misfolding Cyclic Amplification (PMCA) technique. Prion seeding activity was identified in a variety of gestational and fetal tissues. Future studies should demonstrate if prions present in fetuses are at sufficient quantities to cause CWD after birth. This data confirms previous findings in other animal species and furthers vertical transmission as a relevant mechanism of CWD dissemination.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Bioensayo
/
Priones
/
Biomarcadores
/
Enfermedad Debilitante Crónica
/
Feto
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
Límite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Sci Rep
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos