Circulatory 25(OH)D and 1,25(OH)2D as differential biomarkers between multiple system atrophy and Parkinson's disease patients.
eNeurologicalSci
; 25: 100369, 2021 Dec.
Article
en En
| MEDLINE
| ID: mdl-34611554
ABSTRACT
BACKGROUND AND PURPOSE:
There is sufficient evidence to support vitamin D's noncalcemic effects and the role of vitamin D deficiency in the development of a wide range of neurological disorders. This study aimed to evaluate whether serum 25(OH)D and 1,25(OH) 2 D could be used as biomarkers to differentiate between healthy subjects (HS), multiple system atrophy (MSA) and Parkinson's disease (PD) patients of both genders.METHODS:
A total of 107 subjects were included in this study, divided into three groups 1- HS (n = 61), 2- MSA patients (n = 19), and 3- PD patients (n = 27). The patients were assessed using UMSARS II, UPDRS III, H&Y, MMSE and MoCA rating scales. The levels of 25(OH)D and 1,25(OH) 2 D in serum were determined using the radioimmunoassay technique.RESULTS:
The levels of 25(OH)D and 1,25(OH) 2 D in HS were 26.85 +/- 7.62 ng/mL and 53.63 +/- 13.66 pg/mL respectively. 25(OH)D levels were lower in both MSA and PD by 61% and 50%, respectively (P = 0.0001 vs. HS). 1,25(OH) 2 D levels were lower in MSA by 29%(P = 0.001 vs HS). There was a correlation between 25(OH)D and 1,25(OH) 2 D in MSA and PD, but not in HS. 1,25(OH) 2 D regressed with MMSE (ß = 0.476, P = 0.04, R 2 = 0.226) in MSA, and with UPDRS III (ß = -0.432, P = 0.024, R 2 = 0.187) and MoCA (ß = 0.582, P = 0.005,R 2 = 0.279) in PD. 25(OH)D displayed considerable differentiative strength between HS and MSA (Wald = 17.123, OR = 0.586, P = 0.0001; AUC = 0.982, sensitivity and Youden index = 0.882, P = 0.0001) and PD (Wald = 18.552, OR = 0.700, P = 0.0001; AUC = 0.943, sensitivity = 0.889, YI = 0.791, P = 0.0001). 1,25(OH) 2 D distinguished MSA from PD (Wald 16.178, OR = 1.117, P = 0.0001; AUC = 0.868, sensitivity = 0.926, Youden index =0.632, P = 0.0001). H&Y exhibited the highest sensitivity, AUC, and significant distinguishing power between MSA and PD.CONCLUSIONS:
Serum 25(OH)D and 1,25(OH) 2 D could be useful biomarkers for MSA and PD. 25(OH)D and H&Y provided the highest sensitivity and group classification characteristics.
1,25(OH)2D, 1,25-dihydroxyvitamin D3 (Calcitriol); 25(OH)D, 25-hydroxyvitamin D3; H&Y, Hoehn &Yahr rating scale; Hoehn & Yahr staging scale; MMSE, Mini mental state examination; MSA, Multiple system atrophy; MoCA, Montreal Cognitive Assessment; Multiple system atrophy; PD, Parkinson's disease; Parkinson's disease; UMSARS, Unified MSA Rating Scale; UPDRS, Unified PD Rating Scale.; Unified MSA rating scale; Unified PD rating scale; Vitamin D
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Banco de datos:
MEDLINE
Idioma:
En
Revista:
ENeurologicalSci
Año:
2021
Tipo del documento:
Article
País de afiliación:
Japón