Treatment of experimental Pseudomonas corneal ulcers with enoxacin, a quinolone antibiotic.
Arch Ophthalmol
; 104(8): 1230-2, 1986 Aug.
Article
en En
| MEDLINE
| ID: mdl-3461752
ABSTRACT
Enoxacin is a broad-spectrum quinolone-derivative antibiotic. In a rabbit model of keratitis caused by a Pseudomonas species, enoxacin (3 mg/mL) was as effective as gentamicin sulfate (3 mg/mL) and enoxacin (10 mg/mL) in reducing viable bacterial counts in corneas after 24 hours of hourly therapy with eye drops. Bacterial counts were reduced by about 5000-fold by enoxacin treatment when compared with placebo-treated controls. Penetration studies of topical enoxacin (3 mg/mL) showed that concentrations in cornea and aqueous humor reached levels above reported minimal inhibitory concentrations when an epithelial defect was present. Further investigation of enoxacin for treatment of ocular disease is warranted.
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Banco de datos:
MEDLINE
Asunto principal:
Infecciones por Pseudomonas
/
Úlcera de la Córnea
/
Antiinfecciosos
/
Naftiridinas
Límite:
Animals
Idioma:
En
Revista:
Arch Ophthalmol
Año:
1986
Tipo del documento:
Article