Customizing lipids from oleaginous microbes: leveraging exogenous and endogenous approaches.
Trends Biotechnol
; 40(4): 482-508, 2022 04.
Article
en En
| MEDLINE
| ID: mdl-34625276
ABSTRACT
To meet the growing demands of the oleochemical industry, tailored lipid sources are expanding to oleaginous microbes. To control the fatty acid composition of microbial lipids, ground-breaking exogenous and endogenous approaches are being developed. Exogenous approaches employ extracellular tools such as product-specific feedstocks, process optimization, elicitors, and magnetic and mechanical energy, whereas endogenous approaches leverage biology through the use of product-specific microbes, adaptive laboratory evolution (ALE), and the creation of custom strains via random and targeted cellular engineering. We consolidate recent advances from both fields into a review that will serve as a resource for those striving to fulfill the vision of microbial cell factories for tailored lipid production.
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Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Ácidos Grasos
/
Biocombustibles
Idioma:
En
Revista:
Trends Biotechnol
Año:
2022
Tipo del documento:
Article
País de afiliación:
Canadá