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Microglia become hypofunctional and release metalloproteases and tau seeds when phagocytosing live neurons with P301S tau aggregates.
Brelstaff, Jack H; Mason, Matthew; Katsinelos, Taxiarchis; McEwan, William A; Ghetti, Bernardino; Tolkovsky, Aviva M; Spillantini, Maria Grazia.
Afiliación
  • Brelstaff JH; Department of Clinical Neurosciences, Clifford Allbutt Building, University of Cambridge, Cambridge CB2 0AH, UK.
  • Mason M; Department of Clinical Neurosciences, Clifford Allbutt Building, University of Cambridge, Cambridge CB2 0AH, UK.
  • Katsinelos T; Department of Clinical Neurosciences, Clifford Allbutt Building, University of Cambridge, Cambridge CB2 0AH, UK.
  • McEwan WA; UK Dementia Research Institute Cambridge, Island Research Building, University of Cambridge, Cambridge CB2 0AH, UK.
  • Ghetti B; Department of Clinical Neurosciences, Clifford Allbutt Building, University of Cambridge, Cambridge CB2 0AH, UK.
  • Tolkovsky AM; UK Dementia Research Institute Cambridge, Island Research Building, University of Cambridge, Cambridge CB2 0AH, UK.
  • Spillantini MG; Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN, USA.
Sci Adv ; 7(43): eabg4980, 2021 Oct 22.
Article en En | MEDLINE | ID: mdl-34669475
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: Sci Adv Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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XML
PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: Sci Adv Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido