Synthesis, Molecular Docking, and Biological Evaluation of 2,3-Diphenylquinoxaline Derivatives as a Tubulin's Colchicine Binding Site Inhibitor Based on Primary Virtual Screening.

Rezaei, Zahra; Asadi, Mehdi; Montazer, Mohammad Nazari; Rezaeiamiri, Elnaz; Bahadorikhalili, Saeed; Amini, Mohsen; Amanlou, Massoud

Rezaei, Zahra; Asadi, Mehdi; Montazer, Mohammad Nazari; Rezaeiamiri, Elnaz; Bahadorikhalili, Saeed; Amini, Mohsen; Amanlou, Massoud.

Afiliación

Rezaei Z; Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical, Sciences, Tehran, Iran.
Asadi M; Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical, Sciences, Tehran, Iran.
Montazer MN; Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical, Sciences, Tehran, Iran.
Rezaeiamiri E; Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical, Sciences, Tehran, Iran.
Bahadorikhalili S; School of Chemistry, College of Science, University of Tehran, Tehran, Iran.
Amini M; Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical, Sciences, Tehran, Iran.
Amanlou M; Drug Design & Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran.

Anticancer Agents Med Chem ; 22(10): 2011-2025, 2022.

Article en En | MEDLINE | ID: mdl-34702157

Asunto(s)

Adenocarcinoma; Antineoplásicos; Animales; Antineoplásicos/química; Sitios de Unión; Línea Celular Tumoral; Proliferación Celular; Colchicina/química; Ensayos de Selección de Medicamentos Antitumorales; Humanos; Ratones; Simulación del Acoplamiento Molecular; Estructura Molecular; Células 3T3 NIH; Relación Estructura-Actividad; Tubulina (Proteína)/metabolismo; Moduladores de Tubulina/química

Palabras clave

Diphenyl quinoxaline; MTT assay; colchicine binding site; combretastatin; tubulin inhibitors; virtual screening

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Adenocarcinoma / Antineoplásicos Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Animals / Humans Idioma: En Revista: Anticancer Agents Med Chem Asunto de la revista: ANTINEOPLASICOS / QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Irán

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