SNPs for Genes Encoding the Mitochondrial Proteins Sirtuin3 and Uncoupling Protein 2 Are Associated With Disease Severity, Type 2 Diabetes, and Outcomes in Patients With Pulmonary Arterial Hypertension and This Is Recapitulated in a New Mouse Model Lacking Both Genes.

Zhang, Yongneng; Zervopoulos, Sotirios D; Boukouris, Aristeidis E; Lorenzana-Carrillo, Maria Areli; Saleme, Bruno; Webster, Linda; Liu, Yongsheng; Haromy, Alois; Tabatabaei Dakhili, Seyed Amirhossein; Ussher, John R; Sutendra, Gopinath; Michelakis, Evangelos D

Zhang, Yongneng; Zervopoulos, Sotirios D; Boukouris, Aristeidis E; Lorenzana-Carrillo, Maria Areli; Saleme, Bruno; Webster, Linda; Liu, Yongsheng; Haromy, Alois; Tabatabaei Dakhili, Seyed Amirhossein; Ussher, John R; Sutendra, Gopinath; Michelakis, Evangelos D.

Afiliación

Zhang Y; Department of Medicine (Cardiology), Faculty of Medicine and Dentistry University of Alberta Edmonton Alberta Canada.
Zervopoulos SD; Department of Medicine (Cardiology), Faculty of Medicine and Dentistry University of Alberta Edmonton Alberta Canada.
Boukouris AE; Department of Medicine (Cardiology), Faculty of Medicine and Dentistry University of Alberta Edmonton Alberta Canada.
Lorenzana-Carrillo MA; Department of Medicine (Cardiology), Faculty of Medicine and Dentistry University of Alberta Edmonton Alberta Canada.
Saleme B; Department of Medicine (Cardiology), Faculty of Medicine and Dentistry University of Alberta Edmonton Alberta Canada.
Webster L; Department of Medicine (Cardiology), Faculty of Medicine and Dentistry University of Alberta Edmonton Alberta Canada.
Liu Y; Department of Medicine (Cardiology), Faculty of Medicine and Dentistry University of Alberta Edmonton Alberta Canada.
Haromy A; Department of Medicine (Cardiology), Faculty of Medicine and Dentistry University of Alberta Edmonton Alberta Canada.
Tabatabaei Dakhili SA; Faculty of Pharmacy and Pharmaceutical Sciences University of Alberta Edmonton Alberta Canada.
Ussher JR; Faculty of Pharmacy and Pharmaceutical Sciences University of Alberta Edmonton Alberta Canada.
Sutendra G; Department of Medicine (Cardiology), Faculty of Medicine and Dentistry University of Alberta Edmonton Alberta Canada.
Michelakis ED; Department of Medicine (Cardiology), Faculty of Medicine and Dentistry University of Alberta Edmonton Alberta Canada.

J Am Heart Assoc ; 10(23): e020451, 2021 12 07.

Article en En | MEDLINE | ID: mdl-34719264

Asunto(s)

Diabetes Mellitus Tipo 2; Polimorfismo de Nucleótido Simple; Hipertensión Arterial Pulmonar; Sirtuina 3; Proteína Desacopladora 2; Animales; Diabetes Mellitus Tipo 2/genética; Modelos Animales de Enfermedad; Humanos; Resistencia a la Insulina/genética; Ratones; Estudios Prospectivos; Hipertensión Arterial Pulmonar/genética; Hipertensión Arterial Pulmonar/terapia; Índice de Severidad de la Enfermedad; Sirtuina 3/genética; Resultado del Tratamiento; Proteína Desacopladora 2/genética

Palabras clave

insulin resistance; mitochondria; plexogenic arteriopathy; pulmonary arterial hypertension; vascular disease; vascular remodeling; vascular smooth muscle cells

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Polimorfismo de Nucleótido Simple / Diabetes Mellitus Tipo 2 / Sirtuina 3 / Proteína Desacopladora 2 / Hipertensión Arterial Pulmonar Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: J Am Heart Assoc Año: 2021 Tipo del documento: Article

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