Improving the ability of CAR-T cells to hit solid tumors: Challenges and strategies.

Zhang, Zheng-Zheng; Wang, Tian; Wang, Xiao-Feng; Zhang, Yu-Qing; Song, Shu-Xia; Ma, Cui-Qing

Zhang, Zheng-Zheng; Wang, Tian; Wang, Xiao-Feng; Zhang, Yu-Qing; Song, Shu-Xia; Ma, Cui-Qing.

Afiliación

Zhang ZZ; Department of Immunology, Hebei Medical University, Key Laboratory of Immune Mechanism and Intervention for Serious Diseases in Hebei Province, Shijiazhuang 050017, Heibei, China.
Wang T; Department of Immunology, Hebei Medical University, Key Laboratory of Immune Mechanism and Intervention for Serious Diseases in Hebei Province, Shijiazhuang 050017, Heibei, China.
Wang XF; Department of Immunology, Hebei Medical University, Key Laboratory of Immune Mechanism and Intervention for Serious Diseases in Hebei Province, Shijiazhuang 050017, Heibei, China.
Zhang YQ; Department of Immunology, Hebei Medical University, Key Laboratory of Immune Mechanism and Intervention for Serious Diseases in Hebei Province, Shijiazhuang 050017, Heibei, China.
Song SX; Department of Immunology, Hebei Medical University, Key Laboratory of Immune Mechanism and Intervention for Serious Diseases in Hebei Province, Shijiazhuang 050017, Heibei, China. Electronic address: 16600549@hebmu.edu.cn.
Ma CQ; Department of Immunology, Hebei Medical University, Key Laboratory of Immune Mechanism and Intervention for Serious Diseases in Hebei Province, Shijiazhuang 050017, Heibei, China. Electronic address: macuiqing@hebmu.edu.cn.

Pharmacol Res ; 175: 106036, 2022 01.

Article en En | MEDLINE | ID: mdl-34920118

Asunto(s)

Inmunoterapia Adoptiva; Neoplasias/terapia; Receptores Quiméricos de Antígenos/inmunología; Animales; Antígenos de Neoplasias/inmunología; Humanos; Tolerancia Inmunológica; Neoplasias/inmunología; Linfocitos T/inmunología; Escape del Tumor; Microambiente Tumoral/inmunología

Palabras clave

Antigenic heterogeneity; Chimeric antigen receptor T cell (CAR-T); Combination therapy; Exhaustion; Persistence; Solid tumor; Tumor microenvironment (TEM)

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Inmunoterapia Adoptiva / Receptores Quiméricos de Antígenos / Neoplasias Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Pharmacol Res Asunto de la revista: FARMACOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: China

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