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A meta-analysis of prospective cohort studies of flavonoid subclasses and stroke risk.
Li, Xue-Qi; Wang, Chong; Yang, Ting; Fan, Ze-Kai; Guo, Xiao-Fei.
Afiliación
  • Li XQ; Institute of Nutrition & Health, Qingdao University, Qingdao, China.
  • Wang C; School of Public Health, Qingdao University, Qingdao, China.
  • Yang T; Institute of Nutrition & Health, Qingdao University, Qingdao, China.
  • Fan ZK; School of Public Health, Qingdao University, Qingdao, China.
  • Guo XF; Institute of Nutrition & Health, Qingdao University, Qingdao, China.
Phytother Res ; 36(3): 1103-1114, 2022 Mar.
Article en En | MEDLINE | ID: mdl-35023220
ABSTRACT
Epidemiological studies indicate that higher intakes of flavonoids are associated with reduced stroke risk, however, which subtypes play significant roles to protect against stroke remain unclear. A systematic literature search in PubMed and Web of Science databases was performed up to Oct. 2021. Flavonoids or their subtypes (flavanol, flavanone, flavone, flavan-3-ol, isoflavone, or anthocyanin) were paired with stoke as the search term. Multivariate-adjusted relative risks (RRs) with 95% confidence intervals (CIs) for the highest versus the lowest category were pooled by using a random-effects model. Dose-response analysis was implemented by using a restricted cubic spline regression model. Ten independent prospective cohort studies with 387,076 participants and 9,564 events were included. Higher intakes of flavanones were inversely associated with stroke risk (RR = 0.85; 95%CI 0.78, 0.93). Dose-response analysis showed that 50 mg/day increment of flavanones was associated with 11% reduction in stroke risk (RR = 0.89; 95%CI 0.84, 0.94). Flavan-3-ols was marginally inversely associated with stroke risk (RR = 0.92; 95%CI 0.82, 1.02). Dose-response analysis showed that 200 mg/day increment of flavan-3-ols was associated with 14% reduction in stroke risk (RR = 0.86; 95%CI 0.75, 0.98). The non-significant association was observed with respect to other flavonoid subclasses. This study demonstrated higher intakes of flavanones and flavan-3-ols were associated with a lower risk of stroke. Dietary intakes of lemon and citrus rich in flavanones and flavan-3-ols might have beneficial functions for the protection against stroke. The findings of these associations of the present study need to be confirmed in other regions and ethnic origins.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Accidente Cerebrovascular / Dieta Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Phytother Res Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2022 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Accidente Cerebrovascular / Dieta Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Phytother Res Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2022 Tipo del documento: Article País de afiliación: China