CEBPß regulation of endogenous IGF-1 in adult sensory neurons can be mobilized to overcome diabetes-induced deficits in bioenergetics and axonal outgrowth.

Aghanoori, Mohamad-Reza; Agarwal, Prasoon; Gauvin, Evan; Nagalingam, Raghu S; Bonomo, Raiza; Yathindranath, Vinith; Smith, Darrell R; Hai, Yan; Lee, Samantha; Jolivalt, Corinne G; Calcutt, Nigel A; Jones, Meaghan J; Czubryt, Michael P; Miller, Donald W; Dolinsky, Vernon W; Mansuy-Aubert, Virginie; Fernyhough, Paul

Aghanoori, Mohamad-Reza; Agarwal, Prasoon; Gauvin, Evan; Nagalingam, Raghu S; Bonomo, Raiza; Yathindranath, Vinith; Smith, Darrell R; Hai, Yan; Lee, Samantha; Jolivalt, Corinne G; Calcutt, Nigel A; Jones, Meaghan J; Czubryt, Michael P; Miller, Donald W; Dolinsky, Vernon W; Mansuy-Aubert, Virginie; Fernyhough, Paul.

Afiliación

Aghanoori MR; Division of Neurodegenerative Disorders, St. Boniface Hospital Albrechtsen Research Centre, Winnipeg, MB, Canada. mohammadreza.aghanoo@ucalgary.ca.
Agarwal P; Dept of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, MB, Canada. mohammadreza.aghanoo@ucalgary.ca.
Gauvin E; Dept of Medical Genetics, Cumming School of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, T2N 4N2, Canada. mohammadreza.aghanoo@ucalgary.ca.
Nagalingam RS; Dept of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, MB, Canada.
Bonomo R; Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB, Canada.
Yathindranath V; School of Electrical Engineering and Computer Science, KTH Royal Institute of Technology, 10044, Stockholm, Sweden.
Smith DR; Division of Neurodegenerative Disorders, St. Boniface Hospital Albrechtsen Research Centre, Winnipeg, MB, Canada.
Hai Y; Department of Physiology and Pathophysiology, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
Lee S; Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Winnipeg, MB, Canada.
Jolivalt CG; Cellular and Molecular Department, Stritch School of Medicine, Loyola University Chicago, Chicago, USA.
Calcutt NA; Kleysen Institute for Advanced Medicine, University of Manitoba, Winnipeg, MB, Canada.
Jones MJ; Division of Neurodegenerative Disorders, St. Boniface Hospital Albrechtsen Research Centre, Winnipeg, MB, Canada.
Czubryt MP; Department of Biochemistry and Medical Genetics, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
Miller DW; Department of Biochemistry and Medical Genetics, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
Dolinsky VW; Department of Pathology, UCSD, La Jolla, San Diego, CA, USA.
Mansuy-Aubert V; Department of Pathology, UCSD, La Jolla, San Diego, CA, USA.
Fernyhough P; Department of Biochemistry and Medical Genetics, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.

Cell Mol Life Sci ; 79(4): 193, 2022 Mar 17.

Article en En | MEDLINE | ID: mdl-35298717

Asunto(s)

Envejecimiento/metabolismo; Axones/patología; Proteína beta Potenciadora de Unión a CCAAT/metabolismo; Diabetes Mellitus Experimental/metabolismo; Diabetes Mellitus Experimental/patología; Metabolismo Energético; Factor I del Crecimiento Similar a la Insulina/metabolismo; Células Receptoras Sensoriales/metabolismo; Animales; Anticuerpos Neutralizantes/farmacología; Axones/efectos de los fármacos; Axones/metabolismo; Secuencia de Bases; Proteína beta Potenciadora de Unión a CCAAT/genética; Respiración de la Célula/efectos de los fármacos; Células Cultivadas; Diabetes Mellitus Experimental/genética; Diabetes Mellitus Tipo 1/genética; Diabetes Mellitus Tipo 1/patología; Diabetes Mellitus Tipo 2/genética; Diabetes Mellitus Tipo 2/patología; Metabolismo Energético/efectos de los fármacos; Ganglios Espinales/efectos de los fármacos; Ganglios Espinales/metabolismo; Regulación de la Expresión Génica/efectos de los fármacos; Glucólisis/efectos de los fármacos; Células HEK293; Humanos; Factor I del Crecimiento Similar a la Insulina/genética; Hígado/metabolismo; Masculino; Mitocondrias/efectos de los fármacos; Mitocondrias/metabolismo; Factores de Transcripción NFATC/metabolismo; Proyección Neuronal/efectos de los fármacos; Polímeros/metabolismo; Regiones Promotoras Genéticas/genética; Transporte de Proteínas/efectos de los fármacos; Ratas Sprague-Dawley; Células Receptoras Sensoriales/patología; Transducción de Señal/efectos de los fármacos

Palabras clave

Diabetic neuropathy; Dorsal root ganglia; IGF-1; Mitochondria; NFAT1; Neurite outgrowth; Neurotrophic factor

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Células Receptoras Sensoriales / Axones / Envejecimiento / Factor I del Crecimiento Similar a la Insulina / Proteína beta Potenciadora de Unión a CCAAT / Diabetes Mellitus Experimental / Metabolismo Energético Tipo de estudio: Prognostic_studies Idioma: En Revista: Cell Mol Life Sci Asunto de la revista: BIOLOGIA MOLECULAR Año: 2022 Tipo del documento: Article País de afiliación: Canadá

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