Emerging Chemical Diversity and Potential Applications of Enzymes in the DMSO Reductase Superfamily.
Annu Rev Biochem
; 91: 475-504, 2022 06 21.
Article
en En
| MEDLINE
| ID: mdl-35320685
ABSTRACT
Molybdenum- and tungsten-dependent proteins catalyze essential processes in living organisms and biogeochemical cycles. Among these enzymes, members of the dimethyl sulfoxide (DMSO) reductase superfamily are considered the most diverse, facilitating a wide range of chemical transformations that can be categorized as oxygen atom installation, removal, and transfer. Importantly, DMSO reductase enzymes provide high efficiency and excellent selectivity while operating under mild conditions without conventional oxidants such as oxygen or peroxides. Despite the potential utility of these enzymes as biocatalysts, such applications have not been fully explored. In addition, the vast majority of DMSO reductase enzymes still remain uncharacterized. In this review, we describe the reactivities, proposed mechanisms, and potential synthetic applications of selected enzymes in the DMSO reductase superfamily. We also highlight emerging opportunities to discover new chemical activity and current challenges in studying and engineering proteins in the DMSO reductase superfamily.
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1
Banco de datos:
MEDLINE
Asunto principal:
Oxidorreductasas
/
Proteínas Hierro-Azufre
Idioma:
En
Revista:
Annu Rev Biochem
Año:
2022
Tipo del documento:
Article