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Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies.
Huang, Ying; Sendzik, Martin; Zhang, Jeff; Gao, Zhenting; Sun, Yongfeng; Wang, Long; Gu, Justin; Zhao, Kehao; Yu, Zhengtian; Zhang, Lijun; Zhang, Qiong; Blanz, Joachim; Chen, Zijun; Dubost, Valérie; Fang, Douglas; Feng, Lijian; Fu, Xingnian; Kiffe, Michael; Li, Ling; Luo, Fangjun; Luo, Xiao; Mi, Yuan; Mistry, Prakash; Pearson, David; Piaia, Alessandro; Scheufler, Clemens; Terranova, Remi; Weiss, Andreas; Zeng, Jue; Zhang, Hailong; Zhang, Jiangwei; Zhao, Mengxi; Dillon, Michael P; Jeay, Sebastien; Qi, Wei; Moggs, Jonathan; Pissot-Soldermann, Carole; Li, En; Atadja, Peter; Lingel, Andreas; Oyang, Counde.
Afiliación
  • Huang Y; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China.
  • Sendzik M; Novartis Institutes for BioMedical Research, 5300 Chiron Way, Emeryville, California 94608, United States.
  • Zhang J; Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
  • Gao Z; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China.
  • Sun Y; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China.
  • Wang L; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China.
  • Gu J; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China.
  • Zhao K; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China.
  • Yu Z; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China.
  • Zhang L; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China.
  • Zhang Q; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China.
  • Blanz J; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China.
  • Chen Z; Novartis Institutes for BioMedical Research, Novartis Campus, 4056 Basel, Switzerland.
  • Dubost V; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China.
  • Fang D; Novartis Institutes for BioMedical Research, Novartis Campus, 4056 Basel, Switzerland.
  • Feng L; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China.
  • Fu X; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China.
  • Kiffe M; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China.
  • Li L; Novartis Institutes for BioMedical Research, Novartis Campus, 4056 Basel, Switzerland.
  • Luo F; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China.
  • Luo X; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China.
  • Mi Y; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China.
  • Mistry P; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China.
  • Pearson D; Novartis Institutes for BioMedical Research, Novartis Campus, 4056 Basel, Switzerland.
  • Piaia A; Novartis Institutes for BioMedical Research, Novartis Campus, 4056 Basel, Switzerland.
  • Scheufler C; Novartis Institutes for BioMedical Research, Novartis Campus, 4056 Basel, Switzerland.
  • Terranova R; Novartis Institutes for BioMedical Research, Novartis Campus, 4056 Basel, Switzerland.
  • Weiss A; Novartis Institutes for BioMedical Research, Novartis Campus, 4056 Basel, Switzerland.
  • Zeng J; Novartis Institutes for BioMedical Research, Novartis Campus, 4056 Basel, Switzerland.
  • Zhang H; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China.
  • Zhang J; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China.
  • Zhao M; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China.
  • Dillon MP; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China.
  • Jeay S; Novartis Institutes for BioMedical Research, 5300 Chiron Way, Emeryville, California 94608, United States.
  • Qi W; Novartis Institutes for BioMedical Research, Novartis Campus, 4056 Basel, Switzerland.
  • Moggs J; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China.
  • Pissot-Soldermann C; Novartis Institutes for BioMedical Research, Novartis Campus, 4056 Basel, Switzerland.
  • Li E; Novartis Institutes for BioMedical Research, Novartis Campus, 4056 Basel, Switzerland.
  • Atadja P; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China.
  • Lingel A; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China.
  • Oyang C; Novartis Institutes for BioMedical Research, 5300 Chiron Way, Emeryville, California 94608, United States.
J Med Chem ; 65(7): 5317-5333, 2022 04 14.
Article en En | MEDLINE | ID: mdl-35352560
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Histonas / Neoplasias Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: China
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Histonas / Neoplasias Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: China