From Antarctica to cancer research: a novel human DNA topoisomerase 1B inhibitor from Antarctic sponge <i>Dendrilla antarctica</i>.

Ottaviani, Alessio; Welsch, Joshua; Agama, Keli; Pommier, Yves; Desideri, Alessandro; Baker, Bill J; Fiorani, Paola

From Antarctica to cancer research: a novel human DNA topoisomerase 1B inhibitor from Antarctic sponge Dendrilla antarctica.

Ottaviani, Alessio; Welsch, Joshua; Agama, Keli; Pommier, Yves; Desideri, Alessandro; Baker, Bill J; Fiorani, Paola.

Afiliación

Ottaviani A; Department of Biology, University of Rome Tor Vergata, Rome, Italy.
Welsch J; Department of Chemistry, University of South Florida, Tampa, FL, USA.
Agama K; Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Pommier Y; Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Desideri A; Department of Biology, University of Rome Tor Vergata, Rome, Italy.
Baker BJ; Department of Chemistry, University of South Florida, Tampa, FL, USA.
Fiorani P; Department of Biology, University of Rome Tor Vergata, Rome, Italy.

J Enzyme Inhib Med Chem ; 37(1): 1404-1410, 2022 Dec.

Article en En | MEDLINE | ID: mdl-35603503

Asunto(s)

Antineoplásicos; Neoplasias; Regiones Antárticas; Antineoplásicos/química; Antineoplásicos/farmacología; ADN/química; ADN-Topoisomerasas de Tipo I/metabolismo; ADN-Topoisomerasas de Tipo II/metabolismo; Humanos; Inhibidores de Topoisomerasa

Palabras clave

Natural product; cancer; drug development; topoisomerase

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias / Antineoplásicos Límite: Humans Idioma: En Revista: J Enzyme Inhib Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Italia

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