Co-expression of DDR2 and IFITM1 promotes breast cancer cell proliferation, migration and invasion and inhibits apoptosis.
J Cancer Res Clin Oncol
; 148(12): 3385-3398, 2022 Dec.
Article
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| MEDLINE
| ID: mdl-35761108
ABSTRACT
PURPOSE:
To investigate the roles of DDR2 and IFITM1 in breast cancer (BC).METHODS:
The expression of DDR2 and IFITM1 in BC tissues and cell lines was measured. DDR2 and/or IFITM1 were knocked down in BT20 and MDA-MB-231 cells, after which the viability, mobility and apoptosis of the cells were tested. Xenograft mouse models were established through subcutaneous tumor transplantation.RESULTS:
DDR2 and IFITM1 were highly expressed in invasive BC tissues and cell lines. Overexpression of DDR2 and/or IFITM1 was associated with poorer clinical outcomes and patient survival. Knockdown of DDR2 or IFITM1 suppressed the viability and invasiveness of BT20 and MDA-MB-231 cells and restrained the growth of xenograft tumors in nude mice. Simultaneous knockdown of IFITM1 and DDR2 surpassed knockdown of IFITM1 alone in suppressing BC development.CONCLUSIONS:
DDR2 and IFITM1 are co-expressed to facilitate the malignant behaviors of BC cells and promote the development of tumors.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
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Receptor con Dominio Discoidina 2
Límite:
Animals
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Female
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Humans
Idioma:
En
Revista:
J Cancer Res Clin Oncol
Año:
2022
Tipo del documento:
Article