Lanostane triterpenoids from the fruiting bodies of Ganoderma hainanense and their cytotoxic activity.
J Asian Nat Prod Res
; 25(4): 342-348, 2023 Apr.
Article
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| MEDLINE
| ID: mdl-35771834
ABSTRACT
Three undescribed lanostane triterpenoids, 24E-en-11-oxo-ganoderiol D (1), 11ß-hydroxy-ganoderiol D (2), and 11ß-hydroxy-lucidone H (3) were isolated from the 80% EtOH extract of the fruiting bodies of Ganoderma hainanense. Structural elucidation of all the compounds were performed by spectral methods such as 1 D and 2 D (1H-1H COSY, HMQC, and HMBC) NMR spectroscopy. All the triterpenoids were in vitro evaluated for their cytotoxic activities against six mammary adenocarcinoma cell lines (MCF7, MDA-MB-231, SK-BR-3, BT-20, HCC38, and AU565). As a result, compound 3 exhibited significant cytotoxic activities against all tested cell lines with IC50 values less than 20 µM.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Triterpenos
/
Ganoderma
/
Antineoplásicos
Idioma:
En
Revista:
J Asian Nat Prod Res
Asunto de la revista:
BOTANICA
/
QUIMICA
Año:
2023
Tipo del documento:
Article
País de afiliación:
China