Cross-Modal Plasticity in Brains Deprived of Visual Input Before Vision.
Annu Rev Neurosci
; 45: 471-489, 2022 07 08.
Article
en En
| MEDLINE
| ID: mdl-35803589
ABSTRACT
Unimodal sensory loss leads to structural and functional changes in both deprived and nondeprived brain circuits. This process is broadly known as cross-modal plasticity. The evidence available indicates that cross-modal changes underlie the enhanced performances of the spared sensory modalities in deprived subjects. Sensory experience is a fundamental driver of cross-modal plasticity, yet there is evidence from early-visually deprived models supporting an additional role for experience-independent factors. These experience-independent factors are expected to act early in development and constrain neuronal plasticity at later stages. Here we review the cross-modal adaptations elicited by congenital or induced visual deprivation prior to vision. In most of these studies, cross-modal adaptations have been addressed at the structural and functional levels. Here, we also appraise recent data regarding behavioral performance in early-visually deprived models. However, further research is needed to explore how circuit reorganization affects their function and what brings about enhanced behavioral performance.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Privación Sensorial
/
Plasticidad Neuronal
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Annu Rev Neurosci
Año:
2022
Tipo del documento:
Article