A Cardiac Amino-Terminal GRK2 Peptide Inhibits Maladaptive Adipocyte Hypertrophy and Insulin Resistance During Diet-Induced Obesity.

Manaserh, Iyad H; Bledzka, Kamila M; Junker, Alex; Grondolsky, Jessica; Schumacher, Sarah M

Manaserh, Iyad H; Bledzka, Kamila M; Junker, Alex; Grondolsky, Jessica; Schumacher, Sarah M.

Afiliación

Manaserh IH; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Bledzka KM; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Junker A; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Grondolsky J; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Schumacher SM; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.

JACC Basic Transl Sci ; 7(6): 563-579, 2022 Jun.

Article en En | MEDLINE | ID: mdl-35818501

Palabras clave

AS160, Akt substrate of 160 kilodaltons; BAT, brown adipose tissue; GRK2; GRK2, G protein-coupled receptor kinase 2; HFD, high-fat diet; HOMA-IR, homeostatic model assessment of insulin resistance; NLC, nontransgenic littermate control; NP, natriuretic peptide; NPR, natriuretic peptide receptor; RER, respiratory exchange ratio; T2D, type II diabetes; Tg, transgenic; beiging; cardioprotection; gWAT, gonadal white adipose tissue; mTOR, mechanistic target of rapamycin protein kinase; metabolism; obesity; ßARKct, cardiac restricted expression of C-terminus domain of GRK2; ßARKnt, cardiac-restricted expression of N-terminus domain of GRK2

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: JACC Basic Transl Sci Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: JACC Basic Transl Sci Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos