Pentachloropseudilin Treatment Impairs Host Cell Invasion by Trypanosoma cruzi.
Chembiochem
; 23(18): e202200349, 2022 09 16.
Article
en En
| MEDLINE
| ID: mdl-35839379
ABSTRACT
Pentachloropseudilin (PClP) is a reversible and allosteric inhibitor of typeâ
1 myosin. Here, we addressed the impact of PClP treatment of Trypanosoma cruzi and mammalian host cell on the parasite migration, cell adhesion and invasion. We observed that PClP was not toxic to either T.â
cruzi or host cell. Moreover, treatment of T.â
cruzi with PClP inhabited parasite motility, host cell adhesion and invasion. Treatment of host cell with PClP also impaired parasite invasion probably by decreasing lysosome migration to the entry site of the parasite. Therefore, PClP treatment impaired fundamental processes necessary for a successful T.â
cruzi infection.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Trypanosoma cruzi
/
Hidrocarburos Clorados
Límite:
Animals
Idioma:
En
Revista:
Chembiochem
Asunto de la revista:
BIOQUIMICA
Año:
2022
Tipo del documento:
Article
País de afiliación:
Brasil