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Prognostic impact of autoimmune disease in oral cavity squamous cell carcinoma.
Pillai, Anjali; Valero, Cristina; Zanoni, Daniella; Navas, Kathleen; Morris, Quaid; Ganly, Ian; Patel, Snehal G.
Afiliación
  • Pillai A; Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Valero C; Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Zanoni D; Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Navas K; Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Morris Q; Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Ganly I; Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Patel SG; Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
J Surg Oncol ; 126(7): 1183-1190, 2022 Dec.
Article en En | MEDLINE | ID: mdl-35870114
ABSTRACT
BACKGROUND AND

OBJECTIVES:

Recent literature has highlighted the role of the host in the prognosis of oral squamous cell carcinoma (OSCC). In this study, we retrospectively examined the impact of autoimmune (AI) disorders as an aspect of the host status on survival outcomes in OSCC patients.

METHODS:

From a departmental database of OSCC patients (n = 1369), 123 patients with an AI disorder were identified. AI and no-AI groups were compared for survival outcomes.

RESULTS:

There were no significant differences in survival between groups for overall survival, disease-specific survival, local, regional, and distant recurrence-free probabilities. However, survival and recurrence-free probabilities were poorer in the AI group versus the no AI group.

CONCLUSION:

Patients with AI disease trended towards worse outcomes. This suggests immune dysregulation in these patients may impact oncologic outcomes.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedades Autoinmunes / Neoplasias de la Boca / Carcinoma de Células Escamosas / Neoplasias de Cabeza y Cuello Tipo de estudio: Observational_studies / Prognostic_studies Límite: Humans Idioma: En Revista: J Surg Oncol Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedades Autoinmunes / Neoplasias de la Boca / Carcinoma de Células Escamosas / Neoplasias de Cabeza y Cuello Tipo de estudio: Observational_studies / Prognostic_studies Límite: Humans Idioma: En Revista: J Surg Oncol Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos