Rh(I)-Catalyzed Coupling of Azides with Boronic Acids Under Neutral Conditions.
Org Lett
; 24(30): 5546-5551, 2022 08 05.
Article
en En
| MEDLINE
| ID: mdl-35880819
ABSTRACT
Because of the importance of polyfunctional amines, C-N bond formation is important in synthetic organic chemistry. Here we present a neutral amination reaction using azides as the nitrogen source and arylboronic acids with a rhodium(I) catalyst to afford alkyl-aryl and aryl-aryl secondary amines. Natural products and pharmaceutical derivatives were applied, and gram-scale reactions were performed, which demonstrated the utility. Mechanistic experiments and DFT calculations suggested that the reaction involves a metal-nitrene intermediate.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Azidas
/
Ácidos Borónicos
Idioma:
En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2022
Tipo del documento:
Article
País de afiliación:
China