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Brain Structure in Acutely Underweight and Partially Weight-Restored Individuals With Anorexia Nervosa: A Coordinated Analysis by the ENIGMA Eating Disorders Working Group.
Walton, Esther; Bernardoni, Fabio; Batury, Victoria-Luise; Bahnsen, Klaas; Larivière, Sara; Abbate-Daga, Giovanni; Andres-Perpiña, Susana; Bang, Lasse; Bischoff-Grethe, Amanda; Brooks, Samantha J; Campbell, Iain C; Cascino, Giammarco; Castro-Fornieles, Josefina; Collantoni, Enrico; D'Agata, Federico; Dahmen, Brigitte; Danner, Unna N; Favaro, Angela; Feusner, Jamie D; Frank, Guido K W; Friederich, Hans-Christoph; Graner, John L; Herpertz-Dahlmann, Beate; Hess, Andreas; Horndasch, Stefanie; Kaplan, Allan S; Kaufmann, Lisa-Katrin; Kaye, Walter H; Khalsa, Sahib S; LaBar, Kevin S; Lavagnino, Luca; Lazaro, Luisa; Manara, Renzo; Miles, Amy E; Milos, Gabriella F; Monteleone, Alessio Maria; Monteleone, Palmiero; Mwangi, Benson; O'Daly, Owen; Pariente, Jose; Roesch, Julie; Schmidt, Ulrike H; Seitz, Jochen; Shott, Megan E; Simon, Joe J; Smeets, Paul A M; Tamnes, Christian K; Tenconi, Elena; Thomopoulos, Sophia I; van Elburg, Annemarie A.
Afiliación
  • Walton E; Department of Psychology, University of Bath, Bath, United Kingdom.
  • Bernardoni F; Translational Developmental Neuroscience Section, Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
  • Batury VL; Translational Developmental Neuroscience Section, Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
  • Bahnsen K; Translational Developmental Neuroscience Section, Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
  • Larivière S; Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec.
  • Abbate-Daga G; Eating Disorders Center for Treatment and Research, University of Turin, Turin, Italy.
  • Andres-Perpiña S; Department of Child and Adolescent Psychiatry and Psychology, Institut Clinic de Neurociències, Hospital Clínic Universitari, Centro de Investigación Biomédica en Red de Salud Mental, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain.
  • Bang L; Norwegian Institute of Public Health, Oslo; Regional Department for Eating Disorders, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
  • Bischoff-Grethe A; Department of Psychiatry, University of California San Diego, La Jolla, California; Eating Disorders Center for Treatment and Research, University of California San Diego, La Jolla, California.
  • Brooks SJ; School of Psychology, Faculty of Health Sciences, Liverpool John Moores University, Liverpool, United Kingdom; Department of Neuroscience, Uppsala University, Sweden.
  • Campbell IC; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; Eating Disorders Unit, Department of Psychological Medicine, King's College London, London, United Kingdom.
  • Cascino G; Section of Neurosciences, Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, Salerno, Italy.
  • Castro-Fornieles J; Department of Child and Adolescent Psychiatry and Psychology, Institut Clinic de Neurociències, Hospital Clínic Universitari, Centro de Investigación Biomédica en Red de Salud Mental, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain.
  • Collantoni E; Department of Neuroscience, University of Padova, Padova, Italy.
  • D'Agata F; Department of Neuroscience, University of Turin, Turin, Italy.
  • Dahmen B; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Rheinisch-Westfälische Technische Hochschule Aachen, Aachen, Germany.
  • Danner UN; Altrecht Eating Disorders Rintveld, Altrecht Mental Health Institute, Zeist, the Netherlands; Faculty of Social Sciences, Utrecht University, Utrecht, the Netherlands.
  • Favaro A; Department of Neuroscience, University of Padova, Padova, Italy; Padova Neuroscience Center, University of Padova, Padova, Italy.
  • Feusner JD; Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada; Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, California.
  • Frank GKW; Department of Psychiatry, University of California San Diego, La Jolla, California; Eating Disorders Center for Treatment and Research, University of California San Diego, La Jolla, California.
  • Friederich HC; Centre for Psychosocial Medicine, Department of General Internal Medicine and Psychosomatics, University Hospital Heidelberg, Heidelberg, Germany.
  • Graner JL; Center for Cognitive Neuroscience, Duke University, Durham, North Carolina.
  • Herpertz-Dahlmann B; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Rheinisch-Westfälische Technische Hochschule Aachen, Aachen, Germany.
  • Hess A; Institute for Pharmacology and Toxicology, University Erlangen-Nuremberg, Erlangen, Germany.
  • Horndasch S; Department of Child and Adolescent Psychiatry, University Clinic Erlangen, Erlangen, Germany.
  • Kaplan AS; Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada.
  • Kaufmann LK; Department of Consultation-Liaison Psychiatry and Psychosomatics, University Hospital Zurich, University of Zurich; Division of Neuropsychology, Department of Psychology, University of Zurich, Zurich, Switzerland.
  • Kaye WH; Department of Psychiatry, University of California San Diego, La Jolla, California; Eating Disorders Center for Treatment and Research, University of California San Diego, La Jolla, California.
  • Khalsa SS; Laureate Institute for Brain Research, University of Tulsa, Tulsa, Oklahoma; Oxley College of Health Sciences, University of Tulsa, Tulsa, Oklahoma.
  • LaBar KS; Center for Cognitive Neuroscience, Duke University, Durham, North Carolina.
  • Lavagnino L; Louis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, Houston Texas.
  • Lazaro L; Department of Child and Adolescent Psychiatry and Psychology, Institut Clinic de Neurociències, Hospital Clínic Universitari, Centro de Investigación Biomédica en Red de Salud Mental, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain.
  • Manara R; Department of Neuroscience, University of Padova, Padova, Italy.
  • Miles AE; Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada.
  • Milos GF; Department of Consultation-Liaison Psychiatry and Psychosomatics, University Hospital Zurich, University of Zurich.
  • Monteleone AM; Department of Psychiatry, University of Campania L. Vanvitelli, Naples, Italy.
  • Monteleone P; Section of Neurosciences, Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, Salerno, Italy.
  • Mwangi B; Louis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, Houston Texas.
  • O'Daly O; Centre for Neuroimaging Studies, King's College London, London, United Kingdom; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
  • Pariente J; Magnetic Resonance Image Core Facility, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.
  • Roesch J; Department of Neuroradiology, University Clinic Erlangen, Erlangen, Germany.
  • Schmidt UH; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; Eating Disorders Unit, Department of Psychological Medicine, King's College London, London, United Kingdom.
  • Seitz J; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Rheinisch-Westfälische Technische Hochschule Aachen, Aachen, Germany.
  • Shott ME; Department of Psychiatry, University of California San Diego, La Jolla, California; Eating Disorders Center for Treatment and Research, University of California San Diego, La Jolla, California.
  • Simon JJ; Centre for Psychosocial Medicine, Department of General Internal Medicine and Psychosomatics, University Hospital Heidelberg, Heidelberg, Germany.
  • Smeets PAM; UMC Utrecht Brain Center, Utrecht University, Utrecht, the Netherlands; Division of Human Nutrition and Health, Wageningen University, Wageningen, the Netherlands.
  • Tamnes CK; Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; PROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.
  • Tenconi E; Department of Neuroscience, University of Padova, Padova, Italy; Padova Neuroscience Center, University of Padova, Padova, Italy.
  • Thomopoulos SI; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California.
  • van Elburg AA; Altrecht Eating Disorders Rintveld, Altrecht Mental Health Institute, Zeist, the Netherlands; Faculty of Social Sciences, Utrecht University, Utrecht, the Netherlands.
Biol Psychiatry ; 92(9): 730-738, 2022 11 01.
Article en En | MEDLINE | ID: mdl-36031441
ABSTRACT

BACKGROUND:

The pattern of structural brain abnormalities in anorexia nervosa (AN) is still not well understood. While several studies report substantial deficits in gray matter volume and cortical thickness in acutely underweight patients, others find no differences, or even increases in patients compared with healthy control subjects. Recent weight regain before scanning may explain some of this heterogeneity. To clarify the extent, magnitude, and dependencies of gray matter changes in AN, we conducted a prospective, coordinated meta-analysis of multicenter neuroimaging data.

METHODS:

We analyzed T1-weighted structural magnetic resonance imaging scans assessed with standardized methods from 685 female patients with AN and 963 female healthy control subjects across 22 sites worldwide. In addition to a case-control comparison, we conducted a 3-group analysis comparing healthy control subjects with acutely underweight AN patients (n = 466) and partially weight-restored patients in treatment (n = 251).

RESULTS:

In AN, reductions in cortical thickness, subcortical volumes, and, to a lesser extent, cortical surface area were sizable (Cohen's d up to 0.95), widespread, and colocalized with hub regions. Highlighting the effects of undernutrition, these deficits were associated with lower body mass index in the AN sample and were less pronounced in partially weight-restored patients.

CONCLUSIONS:

The effect sizes observed for cortical thickness deficits in acute AN are the largest of any psychiatric disorder investigated in the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Consortium to date. These results confirm the importance of considering weight loss and renutrition in biomedical research on AN and underscore the importance of treatment engagement to prevent potentially long-lasting structural brain changes in this population.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Anorexia Nerviosa Tipo de estudio: Clinical_trials / Observational_studies / Risk_factors_studies / Systematic_reviews Límite: Female / Humans Idioma: En Revista: Biol Psychiatry Año: 2022 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Anorexia Nerviosa Tipo de estudio: Clinical_trials / Observational_studies / Risk_factors_studies / Systematic_reviews Límite: Female / Humans Idioma: En Revista: Biol Psychiatry Año: 2022 Tipo del documento: Article País de afiliación: Reino Unido