Molecular clones of genetically distinct hepatitis B virus genotypes reveal distinct host and drug treatment responses.

Liu, Yongzhen; Park, Debby; Cafiero, Thomas R; Bram, Yaron; Chandar, Vasuretha; Tseng, Anna; Gertje, Hans P; Crossland, Nicholas A; Su, Lishan; Schwartz, Robert E; Ploss, Alexander

Liu, Yongzhen; Park, Debby; Cafiero, Thomas R; Bram, Yaron; Chandar, Vasuretha; Tseng, Anna; Gertje, Hans P; Crossland, Nicholas A; Su, Lishan; Schwartz, Robert E; Ploss, Alexander.

Afiliación

Liu Y; Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, NJ, USA.
Park D; Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, NJ, USA.
Cafiero TR; Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, NJ, USA.
Bram Y; Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Chandar V; Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Tseng A; National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, USA.
Gertje HP; Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA, USA.
Crossland NA; National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, USA.
Su L; National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, USA.
Schwartz RE; Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA, USA.
Ploss A; Division of Virology, Pathogenesis and Cancer, Institute of Human Virology, Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD, USA.

JHEP Rep ; 4(9): 100535, 2022 Sep.

Article en En | MEDLINE | ID: mdl-36035359

Palabras clave

AAV, adeno-associated virus; ALT, alanine aminotransferase; BCP, basic core promoter; CHB, chronic hepatitis B; CpAM, core protein allosteric modulators; DR, direct repeat; ETV, entecavir; En, enhancer; GT(s), genotype(s); HBV, hepatitis B virus; HBVcc, cell culture-derived HBV; HCC, hepatocellular carcinoma; HDI, hydrodynamic injection; IFN, interferon; IHC, immunohistochemistry; IL, interleukin; MOI, multiplicity of infection; NA, nucleos(t)ide analogue; NRG, NODRag1−/−IL2RÎ³NULL; PHH, primiary human hepatocyte; SVR, sustained virologic response; cccDNA, covalently closed circular DNA; dpi, days post infection; drug development; genotypes; hepatitis B; hepatitis B virus; host responses; pgRNA, pre-genomic RNA; reverse genetics; viral hepatitis

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Texto completo: 1 Banco de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: JHEP Rep Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos

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