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SARS-CoV-2 vaccination and risk of severe COVID-19 outcomes in patients with autoimmune hepatitis.
Efe, Cumali; Tasçilar, Koray; Gerussi, Alessio; Bolis, Francesca; Lammert, Craig; Ebik, Berat; Stättermayer, Albert Friedrich; Cengiz, Mustafa; Gökçe, Dilara Turan; Cristoferi, Laura; Peralta, Mirta; Massoumi, Hatef; Montes, Pedro; Cerda, Eira; Rigamonti, Cristina; Yapali, Suna; Adali, Gupse; Çaliskan, Ali Riza; Balaban, Yasemin; Eren, Fatih; Eskazan, Tugçe; Barutçu, Sezgin; Lytvyak, Ellina; Zazueta, Godolfino Miranda; Kayhan, Meral Akdogan; Heurgue-Berlot, Alexandra; De Martin, Eleonora; Yavuz, Ahmet; Biyik, Murat; Narro, Graciela Castro; Duman, Serkan; Hernandez, Nelia; Gatselis, Nikolaos K; Aguirre, Jonathan; Idilman, Ramazan; Silva, Marcelo; Mendizabal, Manuel; Atay, Kadri; Güzelbulut, Fatih; Dhanasekaran, Renumathy; Montano-Loza, Aldo J; Dalekos, George N; Ridruejo, Ezequiel; Invernizzi, Pietro; Wahlin, Staffan.
Afiliación
  • Efe C; Department of Gastroenterology, Harran University Hospital, Sanliurfa, Turkey. Electronic address: scumaliefe@gmail.com.
  • Tasçilar K; Department of Medicine 3-Rheumatology and Immunology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany.
  • Gerussi A; Division of Gastroenterology and Center for Autoimmune Liver Diseases, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), San Gerardo Hospital, Monza, Italy.
  • Bolis F; Division of Gastroenterology and Center for Autoimmune Liver Diseases, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
  • Lammert C; Department of Medicine Indiana, University School of Medicine, Indianapolis, IN, USA.
  • Ebik B; Department of Gastroenterology, Gazi Yasargil Education and Research Hospital, Diyarbakir, Turkey.
  • Stättermayer AF; Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
  • Cengiz M; Department of Gastroenterology, Gülhane Training and Research Hospital, Ankara, Turkey.
  • Gökçe DT; Department of Gastroenterology, Ankara City Hospital, Ankara, Turkey.
  • Cristoferi L; Division of Gastroenterology and Center for Autoimmune Liver Diseases, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), San Gerardo Hospital, Monza, Italy.
  • Peralta M; Hepatology Section, Hospital Francisco J Muñiz, Ciudad Autónoma de Buenos Aires, Argentina; Latin American Liver Research Educational and Awareness Network (LALREAN), Pilar, Argentina.
  • Massoumi H; Department of Medicine, Montefiore Medical Center, Bronx, NY, USA.
  • Montes P; Gastroenterology and Hepatology Unit, Hospital Nacional Daniel A. Carrión, Callao, Peru.
  • Cerda E; Hepatology Unit, Hospital Militar Central de México, Ciudad de México, Mexico.
  • Rigamonti C; Department of Translational Medicine, Università del Piemonte Orientale UPO, Novara, Italy; Division of Internal Medicine, "AOU Maggiore della Carità", Novara, Italy.
  • Yapali S; Department of Gastroenterology, Acibadem University School of Medicine, Istanbul, Turkey.
  • Adali G; Department of Gastroenterology, Umraniye Education and Research Hospital, Istanbul, Turkey.
  • Çaliskan AR; Department of Gastroenterology, Adiyaman University, Adiyaman, Turkey.
  • Balaban Y; Department of Gastroenterology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
  • Eren F; Department of Gastroenterology, Medical Faculty, Uludag University, Bursa, Turkey.
  • Eskazan T; Department of Gastroenterology, Cerrahpasa School of Medicine, Istanbul, Turkey.
  • Barutçu S; Department of Gastroenterology, University of Gaziantep Medical Faculty, Gaziantep, Turkey.
  • Lytvyak E; University of Alberta Division of Gastroenterology and Liver Unit, Edmonton, AB, Canada.
  • Zazueta GM; Gastroenterology Unit, Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", Ciudad de México, Mexico.
  • Kayhan MA; Department of Gastroenterology, Gülhane Training and Research Hospital, Ankara, Turkey.
  • Heurgue-Berlot A; Department of Hepato-Gastroenterology, CHU Reims, Reims, France.
  • De Martin E; Centre Hepato-Biliaire, Hôpital Paul-Brousse, FHU Hepatinov, INSERM Unit UMR 1193, Univ Paris-Saclay, France.
  • Yavuz A; Division of Gastroenterology, Necmettin Erbakan University, Meram School of Medicine, Konya, Turkey.
  • Biyik M; Division of Gastroenterology, Necmettin Erbakan University, Meram School of Medicine, Konya, Turkey.
  • Narro GC; Gastroenterology Unit, Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", Ciudad de México, Mexico.
  • Duman S; Department of Gastroenterology, Ankara University Medical Faculty, Ankara, Turkey.
  • Hernandez N; Gastroenterology and Hepatology Unit, Hospital de Clínicas, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.
  • Gatselis NK; Department of Medicine and Research Laboratory of Internal Medicine, National Expertise Center of Greece in Autoimmune Liver Diseases, General University Hospital of Larissa, Greece; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), General University Hospital of Larissa, Lariss
  • Aguirre J; Hepatology Unit, Hospital Ángeles Pedregal, Ciudad de México, Mexico.
  • Idilman R; Department of Gastroenterology, Ankara University Medical Faculty, Ankara, Turkey.
  • Silva M; Latin American Liver Research Educational and Awareness Network (LALREAN), Pilar, Argentina; Hepatology and Liver Transplant Unit, Hospital Universitario Austral, Pilar, Argentina.
  • Mendizabal M; Latin American Liver Research Educational and Awareness Network (LALREAN), Pilar, Argentina; Hepatology and Liver Transplant Unit, Hospital Universitario Austral, Pilar, Argentina.
  • Atay K; Department of Gastroenterology, Mardin State Hospital, Mardin, Turkey.
  • Güzelbulut F; Department of Gastroenterology, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey.
  • Dhanasekaran R; Division of Gastroenterology and Hepatology, Stanford University, Stanford, CA, USA.
  • Montano-Loza AJ; University of Alberta Division of Gastroenterology and Liver Unit, Edmonton, AB, Canada.
  • Dalekos GN; Department of Medicine and Research Laboratory of Internal Medicine, National Expertise Center of Greece in Autoimmune Liver Diseases, General University Hospital of Larissa, Greece; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), General University Hospital of Larissa, Lariss
  • Ridruejo E; Latin American Liver Research Educational and Awareness Network (LALREAN), Pilar, Argentina; Hepatology and Liver Transplant Unit, Hospital Universitario Austral, Pilar, Argentina; Hepatology Section, Department of Medicine, Centro de Educación Médica e Investigaciones Clínicas, CEMIC, Ciudad Autóno
  • Invernizzi P; Division of Gastroenterology and Center for Autoimmune Liver Diseases, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), San Gerardo Hospital, Monza, Italy.
  • Wahlin S; Hepatology Division, Department of Upper GI Diseases, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
J Autoimmun ; 132: 102906, 2022 10.
Article en En | MEDLINE | ID: mdl-36088883
ABSTRACT

BACKGROUND:

Data regarding outcome of Coronavirus disease 2019 (COVID-19) in vaccinated patients with autoimmune hepatitis (AIH) are lacking. We evaluated the outcome of COVID-19 in AIH patients who received at least one dose of Pfizer- BioNTech (BNT162b2), Moderna (mRNA-1273) or AstraZeneca (ChAdOx1-S) vaccine. PATIENTS AND

METHODS:

We performed a retrospective study on AIH patients with COVID-19. The outcomes of AIH patients who had acute respiratory syndrome coronavirus 2 (SARS-CoV-2) breakthrough infection after at least one dose of COVID-19 vaccine were compared to unvaccinated patients with AIH. COVID-19 outcome was classified according to clinical state during the disease course as (i) no hospitalization, (ii) hospitalization without oxygen supplementation, (iii) hospitalization with oxygen supplementation by nasal cannula or mask, (iv) intensive care unit (ICU) admission with non-invasive mechanical ventilation, (v) ICU admission with invasive mechanical ventilation or (vi) death, and data was analyzed using ordinal logistic regression.

RESULTS:

We included 413 (258 unvaccinated and 155 vaccinated) patients (81%, female) with a median age of 52 (range 17-85) years at COVID-19 diagnosis. The rates of hospitalization were (36.4% vs. 14.2%), need for any supplemental oxygen (29.5% vs. 9%) and mortality (7% vs. 0.6%) in unvaccinated and vaccinated AIH patients with COVID-19. Having received at least one dose of SARS-CoV-2 vaccine was associated with a significantly lower risk of worse COVID-19 severity, after adjusting for age, sex, comorbidities and presence of cirrhosis (adjusted odds ratio [aOR] 0.18, 95% confidence interval [CI], 0.10-0.31). Overall, vaccination against SARS-CoV-2 was associated with a significantly lower risk of mortality from COVID-19 (aOR 0.20, 95% CI 0.11-0.35).

CONCLUSIONS:

SARS-CoV-2 vaccination significantly reduced the risk of COVID-19 severity and mortality in patients with AIH.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Hepatitis Autoinmune / COVID-19 Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Autoimmun Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2022 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Hepatitis Autoinmune / COVID-19 Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Autoimmun Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2022 Tipo del documento: Article