The N-terminal disease-associated R5L Tau mutation increases microtubule shrinkage rate due to disruption of microtubule-bound Tau patches.

Cario, Alisa; Wickramasinghe, Sanjula P; Rhoades, Elizabeth; Berger, Christopher L

Cario, Alisa; Wickramasinghe, Sanjula P; Rhoades, Elizabeth; Berger, Christopher L.

Afiliación

Cario A; Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont, USA.
Wickramasinghe SP; Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Rhoades E; Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Chemistry, University of Pennsylvania, Philadelphia, PA, USA.
Berger CL; Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont, USA. Electronic address: cberger@uvm.edu.

J Biol Chem ; 298(11): 102526, 2022 11.

Article en En | MEDLINE | ID: mdl-36162501

Asunto(s)

Parálisis Supranuclear Progresiva; Tauopatías; Proteínas tau; Humanos; Microtúbulos/metabolismo; Microtúbulos/patología; Mutación; Parálisis Supranuclear Progresiva/genética; Parálisis Supranuclear Progresiva/metabolismo; Proteínas tau/genética; Proteínas tau/metabolismo; Tauopatías/genética; Tauopatías/metabolismo

Palabras clave

FRET; TIRF microscopy; Tau protein; fluorescence correlation spectroscopy; microtubule dynamics; microtubule-associated protein; tauopathy

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Parálisis Supranuclear Progresiva / Proteínas tau / Tauopatías Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: J Biol Chem Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos

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