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Enantioselective C2-H Alkylation of Pyridines with 1,3-Dienes via Ni-Al Bimetallic Catalysis.
Li, Jiang-Fei; Pan, Deng; Wang, Hao-Rui; Zhang, Tao; Li, Yi; Huang, Genping; Ye, Mengchun.
Afiliación
  • Li JF; State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Frontiers Science Center for New Organic Matter, Tianjin 300071, China.
  • Pan D; Department of Chemistry, School of Science and Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Tianjin University, Tianjin 300072, China.
  • Wang HR; State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Frontiers Science Center for New Organic Matter, Tianjin 300071, China.
  • Zhang T; State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Frontiers Science Center for New Organic Matter, Tianjin 300071, China.
  • Li Y; State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Frontiers Science Center for New Organic Matter, Tianjin 300071, China.
  • Huang G; Department of Chemistry, School of Science and Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Tianjin University, Tianjin 300072, China.
  • Ye M; State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Frontiers Science Center for New Organic Matter, Tianjin 300071, China.
J Am Chem Soc ; 144(41): 18810-18816, 2022 10 19.
Article en En | MEDLINE | ID: mdl-36205623
ABSTRACT
A chiral phosphine oxide-ligated Ni-Al bimetallic catalyst was used to realize an enantioselective C2-H alkylation of pyridines without the need of a C2-block. A wide range of pyridines, including unsubstituted pyridine, C3, C4, and C2-substituted pyridines, and even complex pyridine-containing bioactive molecules are well compatible with the reaction, providing up to 81% yield and up to 97% ee.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Polienos / Piridinas Idioma: En Revista: J Am Chem Soc Año: 2022 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Polienos / Piridinas Idioma: En Revista: J Am Chem Soc Año: 2022 Tipo del documento: Article País de afiliación: China