PI3K Isoforms in Cell Signalling and Innate Immune Cell Responses.
Curr Top Microbiol Immunol
; 436: 147-164, 2022.
Article
en En
| MEDLINE
| ID: mdl-36243843
ABSTRACT
Phosphoinositide-3-kinases (PI3Ks) are enzymes involved in signalling and modification of the function of all mammalian cells. These enzymes phosphorylate the 3-hydroxyl group of the inositol ring of phosphatidylinositol, resulting in lipid products that act as second messengers responsible for coordinating many cellular functions, including activation, chemotaxis, proliferation and survival. The identification of the functions that are mediated by a specific PI3K isoform is complex and depends on the specific cell type and inflammatory context. In this chapter we will focus on the role of PI3K isoforms in the context of innate immunity, focusing on the mechanisms by which PI3K signalling regulates phagocytosis, the activation of immunoglobulin, chemokine and cytokines receptors, production of ROS and cell migration, and how PI3K signalling plays a central role in host defence against infections and tissue injury.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Fosfatidilinositol 3-Quinasas
/
Inmunidad Innata
Límite:
Animals
Idioma:
En
Revista:
Curr Top Microbiol Immunol
Año:
2022
Tipo del documento:
Article
País de afiliación:
Brasil