Dexmedetomidine attenuates renal ischemia-reperfusion injury through activating PI3K/Akt-eNOS signaling via &#945;<sub>2</sub> adrenoreceptors in renal microvascular endothelial cells.

Shan, Xisheng; Zhang, Jiaxin; Wei, Xiang; Tao, Wenhui; Peng, Ke; Liu, Huayue; Wang, Yiqing; Liu, Hong; Meng, Xiaowen; Ji, Fuhai

Dexmedetomidine attenuates renal ischemia-reperfusion injury through activating PI3K/Akt-eNOS signaling via α₂ adrenoreceptors in renal microvascular endothelial cells.

Shan, Xisheng; Zhang, Jiaxin; Wei, Xiang; Tao, Wenhui; Peng, Ke; Liu, Huayue; Wang, Yiqing; Liu, Hong; Meng, Xiaowen; Ji, Fuhai.

Afiliación

Shan X; Department of Anesthesiology, the First Affiliated Hospital of Soochow University, Suzhou, China.
Zhang J; Institute of Anesthesiology, Soochow University, Suzhou, China.
Wei X; Department of Anesthesiology, the First Affiliated Hospital of Soochow University, Suzhou, China.
Tao W; Department of Anesthesiology, the First Affiliated Hospital of Soochow University, Suzhou, China.
Peng K; Department of Anesthesiology, the First Affiliated Hospital of Soochow University, Suzhou, China.
Liu H; Department of Anesthesiology, the First Affiliated Hospital of Soochow University, Suzhou, China.
Wang Y; Institute of Anesthesiology, Soochow University, Suzhou, China.
Liu H; Department of Anesthesiology, the First Affiliated Hospital of Soochow University, Suzhou, China.
Meng X; Institute of Anesthesiology, Soochow University, Suzhou, China.
Ji F; Department of Neurology, the First Affiliated Hospital of Soochow University, Suzhou, China.

FASEB J ; 36(11): e22608, 2022 11.

Article en En | MEDLINE | ID: mdl-36250975

Asunto(s)

Dexmedetomidina; Daño por Reperfusión; Animales; Dexmedetomidina/metabolismo; Dexmedetomidina/farmacología; Células Endoteliales/metabolismo; Inflamación/metabolismo; Ratones; Fosfatidilinositol 3-Quinasas/metabolismo; Proteínas Proto-Oncogénicas c-akt/metabolismo; Daño por Reperfusión/tratamiento farmacológico; Daño por Reperfusión/metabolismo; Transducción de Señal

Palabras clave

PI3K/Akt; dexmedetomidine; endothelial nitric oxide synthase; microvascular endothelial cell; renal ischemia and reperfusion injury; α2 adrenoreceptors

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Daño por Reperfusión / Dexmedetomidina Límite: Animals Idioma: En Revista: FASEB J Asunto de la revista: BIOLOGIA / FISIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: China

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