CGRP-induced migraine-like headache in persistent post-traumatic headache attributed to mild traumatic brain injury.
J Headache Pain
; 23(1): 135, 2022 Oct 17.
Article
en En
| MEDLINE
| ID: mdl-36253732
ABSTRACT
OBJECTIVE:
To ascertain whether intravenous infusion of calcitonin gene-related peptide (CGRP) can induce migraine-like headache in people with persistent post-traumatic headache attributed to mild traumatic brain injury (TBI) and no pre-existing migraine.METHODS:
A non-randomized, single-arm, open-label study at a single site in Denmark. Eligible participants were aged 18 to 65 years and had a known history of persistent post-traumatic headache attributed to mild TBI for ≥ 12 months. All participants received continuous intravenous infusion of CGRP (1.5 µg/min) over 20 min. A headache diary was used to collect outcome data until 12 h after the start of CGRP infusion. The primary end point was the incidence of migraine-like headache during 12-hour observational period.RESULTS:
A total of 60 participants completed the study protocol and provided data for the analysis of the primary end point. The median age was 32.5 (IQR, 25.5-43.0) years; 43 participants (72%) were female. Following CGRP infusion, 43 (72%) of 60 participants developed migraine-like headache during the 12-hour observational period. The median time to peak headache intensity was 40 min (IQR, 20-60), and the median peak headache intensity was 6 (IQR, 5-8) on the 11-point numeric rating scale.CONCLUSION:
Intravenous infusion of CGRP is a potent inducer of migraine-like headache in people with persistent post-traumatic headache attributed to mild TBI. This observation underscores the importance of CGRP in the genesis of migraine-like headache that is often experienced by individuals who are afflicted by persistent post-traumatic headache. Further research is warranted to ascertain whether other signaling molecules also contribute to the disease mechanisms underlying post-traumatic headache.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Conmoción Encefálica
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Cefalea de Tipo Tensional
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Cefalea Postraumática
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Trastornos Migrañosos
Tipo de estudio:
Clinical_trials
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Etiology_studies
Límite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
J Headache Pain
Asunto de la revista:
MEDICINA INTERNA
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NEUROLOGIA
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PSICOFISIOLOGIA
Año:
2022
Tipo del documento:
Article
País de afiliación:
Estados Unidos