Nonparametric Bayesian functional selection in 1-M matched case-crossover studies.
Stat Methods Med Res
; 32(1): 133-150, 2023 01.
Article
en En
| MEDLINE
| ID: mdl-36267024
ABSTRACT
The matched case-crossover study has been used in many areas such as public health, biomedical, and epidemiological research for humans, animals, and other subjects with clustered binary outcomes. The control information for each stratum is based on the subject's exposure experience, and the stratifying variable is the individual subject. It is generally accepted that any effects associated with the matching covariates by stratum can be removed in the conditional logistic regression model. However, when there are numerous covariates, it is important to perform variable selection to study the functional association between the variables and the relative risk of diseases or clustered binary outcomes by simultaneously adjusting effect modifications. The methods for simultaneously evaluating effect modifications by matching covariates such as time, as well as performing automatic variable and functional selections under semiparametric model frameworks, are quite limited. In this article, we propose a unified Bayesian approach due to its ability to detect both parametric and nonparametric relationships between the predictors and the relative risk of diseases or binary outcomes, accounting for potential effect modifications by matching covariates such as time, and perform automatic variable and functional selections. We demonstrate the advantages of our approach using simulation study and an epidemiological example of a 1-4 bidirectional case-crossover study.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Estudios Cruzados
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Stat Methods Med Res
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos