Epidemic, risk factors of carbapenem-resistant Klebsiella pneumoniae infection and its effect on the early prognosis of liver transplantation.
Front Cell Infect Microbiol
; 12: 976408, 2022.
Article
en En
| MEDLINE
| ID: mdl-36275019
ABSTRACT
Background:
Carbapenem-resistant Klebsiella pneumoniae (CRKP) infection remains a major cause of morbidity and mortality in early-stage post-liver transplantation (LT).Methods:
We retrospectively analyzed the demographic and clinical infections characteristics of all LT recipients in our hospital between January 2019 and December 2021.Results:
Among the 272 LT recipients who received LT between January 2019 and December 2021, sixty-two patients had at least one infection within 3-months post-LT, with a prevalence of 22.8% (62/272). The prevalence of CRKP infections was 7.0% (19/272), and the 3-months post-LT mortality was 19.4% (12/62). The risk factors independently related to 3-months mortality were age (Odds ratio (OR)= 1.126, 95% Confidence interval (CI) 1.009~1.257; P=0.034), mechanical ventilation (MV) (OR=1.206, 95% CI 1.039~1.401; P =0.014), and CRKP infection (OR=18.240, 95% CI 2.206~150.842; P =0.007). In CRKP infection, the length of ICU stay (OR=1.067, 95% CI 1.015~1.122; P=0.011), pre-operation infection (POI) (OR=6.733, 95% CI 1.160~39.088; P=0.034), and hepatocellular carcinoma (HCC) (OR=26.772, 95% CI 1.747~410.187; P=0.018) were the independent risk factors. With COX multivariate regression analysis, the 3-months survival rate of CRKP infected patients was significantly lower than that without CRKP infection post-LT.Conclusions:
CRKP infection is closely correlated with poor prognosis in 3-months post-LT.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Infecciones por Klebsiella
/
Trasplante de Hígado
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Carcinoma Hepatocelular
/
Enterobacteriaceae Resistentes a los Carbapenémicos
/
Neoplasias Hepáticas
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Front Cell Infect Microbiol
Año:
2022
Tipo del documento:
Article
País de afiliación:
China