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An arrayed CRISPR screen reveals Myc depletion to increase productivity of difficult-to-express complex antibodies in CHO cells.
Bauer, Niels; Oswald, Benedikt; Eiche, Maximilian; Schiller, Lisa; Langguth, Emma; Schantz, Christian; Osterlehner, Andrea; Shen, Amy; Misaghi, Shahram; Stingele, Julian; Ausländer, Simon.
Afiliación
  • Bauer N; Large Molecule Research, Roche Pharma Research and Early Development (pRED), Roche Innovation Center Munich, Penzberg, Germany.
  • Oswald B; Gene Center and Department of Biochemistry, Ludwig-Maximilians-University Munich, Munich 81377, Germany.
  • Eiche M; Large Molecule Research, Roche Pharma Research and Early Development (pRED), Roche Innovation Center Munich, Penzberg, Germany.
  • Schiller L; Large Molecule Research, Roche Pharma Research and Early Development (pRED), Roche Innovation Center Munich, Penzberg, Germany.
  • Langguth E; Large Molecule Research, Roche Pharma Research and Early Development (pRED), Roche Innovation Center Munich, Penzberg, Germany.
  • Schantz C; Large Molecule Research, Roche Pharma Research and Early Development (pRED), Roche Innovation Center Munich, Penzberg, Germany.
  • Osterlehner A; Large Molecule Research, Roche Pharma Research and Early Development (pRED), Roche Innovation Center Munich, Penzberg, Germany.
  • Shen A; Large Molecule Research, Roche Pharma Research and Early Development (pRED), Roche Innovation Center Munich, Penzberg, Germany.
  • Misaghi S; Cell Culture and Bioprocess Operations Department, Genentech Inc., South San Francisco, CA, USA.
  • Stingele J; Cell Culture and Bioprocess Operations Department, Genentech Inc., South San Francisco, CA, USA.
  • Ausländer S; Gene Center and Department of Biochemistry, Ludwig-Maximilians-University Munich, Munich 81377, Germany.
Synth Biol (Oxf) ; 7(1): ysac026, 2022.
Article en En | MEDLINE | ID: mdl-36452067
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: Synth Biol (Oxf) Año: 2022 Tipo del documento: Article País de afiliación: Alemania
Texto completo
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XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: Synth Biol (Oxf) Año: 2022 Tipo del documento: Article País de afiliación: Alemania