BCR-UNet: Bi-directional ConvLSTM residual U-Net for retinal blood vessel segmentation.

Background: High precision segmentation of retinal blood vessels from retinal images is a significant step for doctors to diagnose many diseases such as glaucoma and cardiovascular diseases. However, at the peripheral region of vessels, previous U-Net-based segmentation methods failed to significantly preserve the low-contrast tiny vessels. Methods: For solving this challenge, we propose a novel network model called Bi-directional ConvLSTM Residual U-Net (BCR-UNet), which takes full advantage of U-Net, Dropblock, Residual convolution and Bi-directional ConvLSTM (BConvLSTM). In this proposed BCR-UNet model, we propose a novel Structured Dropout Residual Block (SDRB) instead of using the original U-Net convolutional block, to construct our network skeleton for improving the robustness of the network. Furthermore, to improve the discriminative ability of the network and preserve more original semantic information of tiny vessels, we adopt BConvLSTM to integrate the feature maps captured from the first residual block and the last up-convolutional layer in a nonlinear manner. Results and discussion: We conduct experiments on four public retinal blood vessel datasets, and the results show that the proposed BCR-UNet can preserve more tiny blood vessels at the low-contrast peripheral regions, even outperforming previous state-of-the-art methods.