Association of Phase Angle with Overall Survival in Patients with Cancer: A Prospective Multicenter Cohort Study.

ABSTRACT

Low phase angle (PhA) is related with poor clinical status of cancer patients. The objective of this study was to establish sex- and age-specific cutoff points and examine the association between PhA and overall survival (OS) in Chinese cancer patients. This cohort study included data on 1,814 patients with cancer from December 2013 to October 2020. The association between low PhA and overall survival was analyzed using the Kaplan-Meier method and Cox regression model. Among 1,814 participants, there were 993 (54.70%) male and 821 (45.30%) female patients. The optimal cutoff points of low PhA were 4.8°, 4.2°, 4.4°, and 3.8° for the young male, elderly male, young female, and elderly female, respectively. Low PhA was independently associated with poorer OS in young female, elderly female and male (HR 1.59, 95% CI 1.08-2.34; HR 1.65, 95% CI 1.03-2.67; HR 2.00, 95% CI 1.45-2.75). In addition, low PhA was demonstrated to be an adverse prognostic factor in patients with lung cancer, colorectal cancer, and esophagus cancer (HR 1.85, 95% CI 1.39-2.47; HR 2.05, 95% CI 1.13-3.70; HR 2.92, 95% CI 1.49-5.71). Based on cutoff points, low PhA was associated with worse prognosis in patients with cancer.