Role of HIF-1α in pathogenic mechanisms of keloids.
J Cosmet Dermatol
; 22(5): 1436-1448, 2023 May.
Article
en En
| MEDLINE
| ID: mdl-36718786
ABSTRACT
BACKGROUDS AND OBJECTIVE:
Keloids are defined as overrepairing products that develop after skin lesions. Keloids are characterized by the proliferation of fibroblasts and the overaccumulation of extracellular matrix components (mainly collagen), leading to a locally hypoxic microenvironment. Hence, this article was aimed to review hypoxia in pathogenesis of keloids.METHODS:
We reviewed and summarized the relevant published studies.RESULTS:
Hypoxia results in the accumulation of hypoxia-inducible factor 1α (HIF-1α) in keloids, contributing to overactivation of the fibrotic signaling pathway, epithelial-mesenchymal transition, and changes in metabolism, eventually leading to aggravated fibrosis, infiltrative growth, and radiotherapy resistance.CONCLUSION:
It is, therefore, essential to understand the role of HIF-1α in the pathogenic mechanisms of keloids in order to develop new therapeutic approaches.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Subunidad alfa del Factor 1 Inducible por Hipoxia
/
Queloide
Límite:
Humans
Idioma:
En
Revista:
J Cosmet Dermatol
Asunto de la revista:
DERMATOLOGIA
Año:
2023
Tipo del documento:
Article
País de afiliación:
China