Structural and molecular insights into tacrine-benzofuran hybrid induced inhibition of amyloid-ß peptide aggregation and BACE1 activity.

Kaur, Rajdeep; Narang, Simranjeet Singh; Singh, Pritpal; Goyal, Bhupesh

Kaur, Rajdeep; Narang, Simranjeet Singh; Singh, Pritpal; Goyal, Bhupesh.

Afiliación

Kaur R; Department of Chemistry, Faculty of Basic and Applied Sciences, Sri Guru Granth Sahib World University, Fatehgarh Sahib, Punjab, India.
Narang SS; Department of Chemistry, Faculty of Basic and Applied Sciences, Sri Guru Granth Sahib World University, Fatehgarh Sahib, Punjab, India.
Singh P; Department of Chemistry, Faculty of Basic and Applied Sciences, Sri Guru Granth Sahib World University, Fatehgarh Sahib, Punjab, India.
Goyal B; School of Chemistry & Biochemistry, Thapar Institute of Engineering & Technology, Patiala, Punjab, India.

J Biomol Struct Dyn ; 41(22): 13211-13227, 2023.

Article en En | MEDLINE | ID: mdl-37013977

Asunto(s)

Enfermedad de Alzheimer; Benzofuranos; Humanos; Péptidos beta-Amiloides/química; Precursor de Proteína beta-Amiloide; Tacrina/farmacología; Secretasas de la Proteína Precursora del Amiloide; Ligandos; Ácido Aspártico Endopeptidasas; Enfermedad de Alzheimer/tratamiento farmacológico; Simulación de Dinámica Molecular; Benzofuranos/farmacología; Fragmentos de Péptidos/química

Palabras clave

Alzheimer's disease; BACE1; MD simulations; amyloid-ß; tacrine-benzofuran hybrid

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Benzofuranos / Enfermedad de Alzheimer Límite: Humans Idioma: En Revista: J Biomol Struct Dyn Año: 2023 Tipo del documento: Article País de afiliación: India

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