Your browser doesn't support javascript.
loading
A model of fluid-structure and biochemical interactions for applications to subclinical leaflet thrombosis.
Barrett, Aaron; Brown, Jordan A; Smith, Margaret Anne; Woodward, Andrew; Vavalle, John P; Kheradvar, Arash; Griffith, Boyce E; Fogelson, Aaron L.
Afiliación
  • Barrett A; Department of Mathematics, University of Utah, Salt Lake City, Utah, USA.
  • Brown JA; Department of Mathematics, University of North Carolina, Chapel Hill, North Carolina, USA.
  • Smith MA; Department of Mathematics, University of North Carolina, Chapel Hill, North Carolina, USA.
  • Woodward A; Advanced Medical Imaging Lab, University of North Carolina Medical Center, Chapel Hill, North Carolina, USA.
  • Vavalle JP; University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
  • Kheradvar A; Division of Cardiology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.
  • Griffith BE; Department of Biomedical Engineering, University of California Irvine, Irvine, California, USA.
  • Fogelson AL; Departments of Mathematics, Applied Physical Sciences, and Biomedical Engineering, University of North Carolina, Chapel Hill, North Carolina, USA.
Int J Numer Method Biomed Eng ; 39(5): e3700, 2023 05.
Article en En | MEDLINE | ID: mdl-37016277
Subclinical leaflet thrombosis (SLT) is a potentially serious complication of aortic valve replacement with a bioprosthetic valve in which blood clots form on the replacement valve. SLT is associated with increased risk of transient ischemic attacks and strokes and can progress to clinical leaflet thrombosis. SLT following aortic valve replacement also may be related to subsequent structural valve deterioration, which can impair the durability of the valve replacement. Because of the difficulty in clinical imaging of SLT, models are needed to determine the mechanisms of SLT and could eventually predict which patients will develop SLT. To this end, we develop methods to simulate leaflet thrombosis that combine fluid-structure interaction and a simplified thrombosis model that allows for deposition along the moving leaflets. Additionally, this model can be adapted to model deposition or absorption along other moving boundaries. We present convergence results and quantify the model's ability to realize changes in valve opening and pressures. These new approaches are an important advancement in our tools for modeling thrombosis because they incorporate both adhesion to the surface of the moving leaflets and feedback to the fluid-structure interaction.
Asunto(s)
Palabras clave

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Estenosis de la Válvula Aórtica / Trombosis / Prótesis Valvulares Cardíacas / Reemplazo de la Válvula Aórtica Transcatéter Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Int J Numer Method Biomed Eng Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Estenosis de la Válvula Aórtica / Trombosis / Prótesis Valvulares Cardíacas / Reemplazo de la Válvula Aórtica Transcatéter Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Int J Numer Method Biomed Eng Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos