Metal coordinating-induced self-assembly of cyclic lipopeptides into high-performance antimicrobial supramolecules.
Food Chem
; 422: 136203, 2023 Oct 01.
Article
en En
| MEDLINE
| ID: mdl-37121207
ABSTRACT
This study designed a green hydrothermally-chelating approach to generate robust antimicrobial complexes via metal-coordinated supramolecular self-assembly of cyclic lipopeptides (CLs). The metal ion (Ca2+ and Zn2+)-coordinated CL (Ca/CL or Zn/CL complex; 1 mg/mL) demonstrated potent antibacterial activity against fungi (A. niger) and bacteria (E. coli and S. aureus) respectively, and in particular, completely suppressed the microbial resistance. Further physicochemical and spectal analysis showed that this coordination approach led to CL with enhanced hydrophobic and intermolecular electrostatic interactions, forming ß-sheet-rich secondary structures allowing the complexes easily contact with and destroy the membrane of microorganisms. Practical application experiments validated that the Ca/CL and Zn/CL complexes strongly avoided table grape and fresh tomato from the contamination of pathogen. The findings of this study laid foundation for the utilization of metal ions to improve the biological activity of natural antimicrobial peptides.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Complejos de Coordinación
/
Antiinfecciosos
Idioma:
En
Revista:
Food Chem
Año:
2023
Tipo del documento:
Article
País de afiliación:
China