Microfluidic 'brain-on chip' systems to supplement neurological practice: development, applications and considerations.
Regen Med
; 18(5): 413-423, 2023 05.
Article
en En
| MEDLINE
| ID: mdl-37125510
In this paper, the authors describe the role of microfluidic 'brain-on-chip' systems as a tool to model and study the human brain. While animal studies have provided significant insights, they lack the complexity of human brain tissue in order to verify the effects of drugs on patients, study complex physiological pathways or personalize regenerative therapies. This makes studying diseases of complex human organs challenging. Microfluidics is a field of study that can address these challenges by developing sophisticated and miniaturized devices that can chamber human tissue. These devices could allow scientists to better study diseases on a model that is accurate and controllable, allowing researchers to better understand complex diseases, assess drug efficacy to specific areas of the brain and potentially accelerate the development of new therapies. Herein, we characterize the principles, development and challenges of microfluidics and the role they have served in different neurological diseases.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Ingeniería de Tejidos
/
Microfluídica
Límite:
Humans
Idioma:
En
Revista:
Regen Med
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos