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Looping the Genome with SMC Complexes.
Kim, Eugene; Barth, Roman; Dekker, Cees.
Afiliación
  • Kim E; Max Planck Institute of Biophysics, Frankfurt am Main, Germany.
  • Barth R; Department of Bionanoscience, Kavli Institute of Nanoscience Delft, Delft University of Technology, Delft, The Netherlands; email: c.dekker@tudelft.nl.
  • Dekker C; Department of Bionanoscience, Kavli Institute of Nanoscience Delft, Delft University of Technology, Delft, The Netherlands; email: c.dekker@tudelft.nl.
Annu Rev Biochem ; 92: 15-41, 2023 06 20.
Article en En | MEDLINE | ID: mdl-37137166
SMC (structural maintenance of chromosomes) protein complexes are an evolutionarily conserved family of motor proteins that hold sister chromatids together and fold genomes throughout the cell cycle by DNA loop extrusion. These complexes play a key role in a variety of functions in the packaging and regulation of chromosomes, and they have been intensely studied in recent years. Despite their importance, the detailed molecular mechanism for DNA loop extrusion by SMC complexes remains unresolved. Here, we describe the roles of SMCs in chromosome biology and particularly review in vitro single-molecule studies that have recently advanced our understanding of SMC proteins. We describe the mechanistic biophysical aspects of loop extrusion that govern genome organization and its consequences.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas Cromosómicas no Histona / Complejos Multiproteicos Idioma: En Revista: Annu Rev Biochem Año: 2023 Tipo del documento: Article País de afiliación: Alemania

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas Cromosómicas no Histona / Complejos Multiproteicos Idioma: En Revista: Annu Rev Biochem Año: 2023 Tipo del documento: Article País de afiliación: Alemania