A high-throughput molecular dynamics screening (HTMDS) approach to the design of novel cyclopeptide inhibitors of ATAD2B based on the non-canonical combinatorial library.
J Biomol Struct Dyn
; 42(6): 2809-2824, 2024 Apr.
Article
en En
| MEDLINE
| ID: mdl-37194299
A high-throughput MD screening (HTMDS) process for cyclic peptides (CPs) binders designed with canonical and non-canonical amino acids.698,800 CP candidates with a total of 25,570 ns MD simulations were performed to study the protein-ligand binding interactions and CP design.Some potent CP candidates were obtained with high binding free energies (ΔGbind) estimated by the MM/PBSA approach compared with the standard inhibitor C-38 against the bromodomain (BrD) of ATAD2B.
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Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Péptidos Cíclicos
/
Simulación de Dinámica Molecular
Tipo de estudio:
Diagnostic_studies
/
Screening_studies
Idioma:
En
Revista:
J Biomol Struct Dyn
Año:
2024
Tipo del documento:
Article
País de afiliación:
China