Your browser doesn't support javascript.
loading
Cardiovascular and metabolic health is associated with functional brain connectivity in middle-aged and older adults: Results from the Human Connectome Project-Aging study.
Rashid, Barnaly; Glasser, Matthew F; Nichols, Thomas; Van Essen, David; Juttukonda, Meher R; Schwab, Nadine A; Greve, Douglas N; Yacoub, Essa; Lovely, Allison; Terpstra, Melissa; Harms, Michael P; Bookheimer, Susan Y; Ances, Beau M; Salat, David H; Arnold, Steven E.
Afiliación
  • Rashid B; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th St., Charlestown, MA 02129, United States; Harvard Medical School, Boston, MA, United States. Electronic address: brashid@mgh.harvard.edu.
  • Glasser MF; Washington University School of Medicine, St. Louis, MO, United States.
  • Nichols T; University of Oxford, Oxford, United Kingdom.
  • Van Essen D; Washington University School of Medicine, St. Louis, MO, United States.
  • Juttukonda MR; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th St., Charlestown, MA 02129, United States; Harvard Medical School, Boston, MA, United States.
  • Schwab NA; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th St., Charlestown, MA 02129, United States; Harvard Medical School, Boston, MA, United States.
  • Greve DN; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th St., Charlestown, MA 02129, United States; Harvard Medical School, Boston, MA, United States.
  • Yacoub E; Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States.
  • Lovely A; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th St., Charlestown, MA 02129, United States; Harvard Medical School, Boston, MA, United States.
  • Terpstra M; University of Minnesota, Minneapolis, MN, United States.
  • Harms MP; Washington University in St. Louis, St. Louis, MO, United States.
  • Bookheimer SY; University of California, Los Angeles, Los Angeles, CA, United States.
  • Ances BM; Washington University School of Medicine, St. Louis, MO, United States; Washington University in St. Louis, St. Louis, MO, United States.
  • Salat DH; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th St., Charlestown, MA 02129, United States; Harvard Medical School, Boston, MA, United States. Electronic address: dsalat@mgh.harvard.edu.
  • Arnold SE; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th St., Charlestown, MA 02129, United States; Harvard Medical School, Boston, MA, United States. Electronic address: searnold@mgh.harvard.edu.
Neuroimage ; 276: 120192, 2023 08 01.
Article en En | MEDLINE | ID: mdl-37247763
Several cardiovascular and metabolic indicators, such as cholesterol and blood pressure have been associated with altered neural and cognitive health as well as increased risk of dementia and Alzheimer's disease in later life. In this cross-sectional study, we examined how an aggregate index of cardiovascular and metabolic risk factor measures was associated with correlation-based estimates of resting-state functional connectivity (FC) across a broad adult age-span (36-90+ years) from 930 volunteers in the Human Connectome Project Aging (HCP-A). Increased (i.e., worse) aggregate cardiometabolic scores were associated with reduced FC globally, with especially strong effects in insular, medial frontal, medial parietal, and superior temporal regions. Additionally, at the network-level, FC between core brain networks, such as default-mode and cingulo-opercular, as well as dorsal attention networks, showed strong effects of cardiometabolic risk. These findings highlight the lifespan impact of cardiovascular and metabolic health on whole-brain functional integrity and how these conditions may disrupt higher-order network integrity.
Asunto(s)
Palabras clave
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Conectoma Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Humans / Middle aged Idioma: En Revista: Neuroimage Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2023 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Conectoma Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Humans / Middle aged Idioma: En Revista: Neuroimage Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2023 Tipo del documento: Article