Discovery of potent NAMPT-Targeting PROTACs using FK866 as the warhead.

Zhang, Peifeng; Wang, Wei; Guo, Menglu; Zhou, Luozhu; Dong, Guoqiang; Xu, Defeng; Sheng, Chunquan

Zhang, Peifeng; Wang, Wei; Guo, Menglu; Zhou, Luozhu; Dong, Guoqiang; Xu, Defeng; Sheng, Chunquan.

Afiliación

Zhang P; School of Pharmacy, Changzhou University, Changzhou 213164, China.
Wang W; School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Guo M; School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Zhou L; School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Dong G; School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Xu D; School of Pharmacy, Changzhou University, Changzhou 213164, China. Electronic address: markxu@cczu.edu.cn.
Sheng C; School of Pharmacy, Second Military Medical University, Shanghai 200433, China. Electronic address: shengcq@smmu.edu.cn.

Bioorg Med Chem Lett ; 92: 129393, 2023 08 15.

Article en En | MEDLINE | ID: mdl-37369332

Asunto(s)

Nicotinamida Fosforribosiltransferasa; Neoplasias Ováricas; Quimera Dirigida a la Proteólisis; Femenino; Humanos; Línea Celular Tumoral; Citocinas/metabolismo; NAD/metabolismo; Nicotinamida Fosforribosiltransferasa/metabolismo; Proteolisis; Quimera Dirigida a la Proteólisis/química

Palabras clave

Degradation potency; Drug discovery; FK866; NAMPT; PROTAC

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Nicotinamida Fosforribosiltransferasa / Quimera Dirigida a la Proteólisis Límite: Female / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: China

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