Scalable manufacturing of gene-modified human mesenchymal stromal cells with microcarriers in spinner flasks.

Couto, Pedro Silva; Stibbs, Dale J; Rotondi, Marco C; Takeuchi, Yasuhiro; Rafiq, Qasim A

Couto, Pedro Silva; Stibbs, Dale J; Rotondi, Marco C; Takeuchi, Yasuhiro; Rafiq, Qasim A.

Afiliación

Couto PS; Department of Biochemical Engineering, Advanced Centre for Biochemical Engineering, University College London, Gower Street, London, WC1E 6BT, UK.
Stibbs DJ; Department of Biochemical Engineering, Advanced Centre for Biochemical Engineering, University College London, Gower Street, London, WC1E 6BT, UK.
Rotondi MC; Department of Biochemical Engineering, Advanced Centre for Biochemical Engineering, University College London, Gower Street, London, WC1E 6BT, UK.
Takeuchi Y; Division of Infection and Immunity, University College London, Gower Street, London, WC1E 6BT, UK.
Rafiq QA; Biotherapeutics and Advanced Therapies, Scientific Research and Innovation, Medicines, and Healthcare Products Regulatory Agency, South Mimms, EN6 3QG, UK.

Appl Microbiol Biotechnol ; 107(18): 5669-5685, 2023 Sep.

Article en En | MEDLINE | ID: mdl-37470820

Asunto(s)

Técnicas de Cultivo de Célula; Células Madre Mesenquimatosas; Humanos; Técnicas de Cultivo de Célula/métodos; Factor A de Crecimiento Endotelial Vascular/metabolismo; Reactores Biológicos; Diferenciación Celular; Proliferación Celular

Palabras clave

Engineering; Gene-modified; Lentiviral vector; Manufacturing; Mesenchymal; Microcarrier

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Técnicas de Cultivo de Célula / Células Madre Mesenquimatosas Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Appl Microbiol Biotechnol Año: 2023 Tipo del documento: Article País de afiliación: Reino Unido

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