Pyrin variant E148Q potentiates inflammasome activation and the effect of pathogenic mutations in cis.

Reygaerts, Thomas; Laohamonthonkul, Pawat; Hrovat-Schaale, Katja; Moghaddas, Fiona; Baker, Paul J; Gray, Paul E; Masters, Seth L

Reygaerts, Thomas; Laohamonthonkul, Pawat; Hrovat-Schaale, Katja; Moghaddas, Fiona; Baker, Paul J; Gray, Paul E; Masters, Seth L.

Afiliación

Reygaerts T; Inflammation Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Laohamonthonkul P; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia.
Hrovat-Schaale K; Inflammation Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Moghaddas F; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia.
Baker PJ; Inflammation Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Gray PE; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia.
Masters SL; Immunology and Allergy Centre, North Bristol NHS Trust, Bristol, UK.

Rheumatology (Oxford) ; 63(3): 882-890, 2024 Mar 01.

Article en En | MEDLINE | ID: mdl-37481715

Asunto(s)

Inflamasomas; Pirina; Humanos; Australia; Toxinas Bacterianas/farmacología; Células HEK293; Inflamasomas/genética; Mutación; Pirina/genética

Palabras clave

FMF; IL-1; cytokines; inflammasome; polymorphism; pyrin; risk factor

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Inflamasomas / Pirina Tipo de estudio: Risk_factors_studies Límite: Humans País/Región como asunto: Oceania Idioma: En Revista: Rheumatology (Oxford) Asunto de la revista: REUMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Australia

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