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Cerebrospinal fluid biomarkers in the Longitudinal Early-onset Alzheimer's Disease Study.
Dage, Jeffrey L; Eloyan, Ani; Thangarajah, Maryanne; Hammers, Dustin B; Fagan, Anne M; Gray, Julia D; Schindler, Suzanne E; Snoddy, Casey; Nudelman, Kelly N H; Faber, Kelley M; Foroud, Tatiana; Aisen, Paul; Griffin, Percy; Grinberg, Lea T; Iaccarino, Leonardo; Kirby, Kala; Kramer, Joel; Koeppe, Robert; Kukull, Walter A; La Joie, Renaud; Mundada, Nidhi S; Murray, Melissa E; Rumbaugh, Malia; Soleimani-Meigooni, David N; Toga, Arthur W; Touroutoglou, Alexandra; Vemuri, Prashanthi; Atri, Alireza; Beckett, Laurel A; Day, Gregory S; Graff-Radford, Neill R; Duara, Ranjan; Honig, Lawrence S; Jones, David T; Masdeu, Joseph C; Mendez, Mario F; Musiek, Erik; Onyike, Chiadi U; Riddle, Meghan; Rogalski, Emily; Salloway, Stephen; Sha, Sharon J; Turner, Raymond S; Wingo, Thomas S; Wolk, David A; Womack, Kyle B; Carrillo, Maria C; Dickerson, Bradford C; Rabinovici, Gil D; Apostolova, Liana G.
Afiliación
  • Dage JL; Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Eloyan A; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Thangarajah M; Department of Biostatistics, Center for Statistical Sciences, Brown University, Providence, Rhode Island, USA.
  • Hammers DB; Department of Biostatistics, Center for Statistical Sciences, Brown University, Providence, Rhode Island, USA.
  • Fagan AM; Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Gray JD; Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA.
  • Schindler SE; Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA.
  • Snoddy C; Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA.
  • Nudelman KNH; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Faber KM; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Foroud T; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Aisen P; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Griffin P; Alzheimer's Therapeutic Research Institute, University of Southern California, San Diego, California, USA.
  • Grinberg LT; Medical & Scientific Relations Division, Alzheimer's Association, Chicago, Illinois, USA.
  • Iaccarino L; Department of Neurology, University of California - San Francisco, San Francisco, California, USA.
  • Kirby K; Department of Pathology, University of California - San Francisco, San Francisco, California, USA.
  • Kramer J; Department of Neurology, University of California - San Francisco, San Francisco, California, USA.
  • Koeppe R; Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Kukull WA; Department of Neurology, University of California - San Francisco, San Francisco, California, USA.
  • La Joie R; Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA.
  • Mundada NS; Department of Epidemiology, University of Washington, Seattle, Washington, USA.
  • Murray ME; Department of Neurology, University of California - San Francisco, San Francisco, California, USA.
  • Rumbaugh M; Department of Neurology, University of California - San Francisco, San Francisco, California, USA.
  • Soleimani-Meigooni DN; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.
  • Toga AW; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Touroutoglou A; Department of Neurology, University of California - San Francisco, San Francisco, California, USA.
  • Vemuri P; Laboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Los Angeles, California, USA.
  • Atri A; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
  • Beckett LA; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
  • Day GS; Banner Sun Health Research Institute, Sun City, Arizona, USA.
  • Graff-Radford NR; Department of Public Health Sciences, University of California-Davis, Davis, California, USA.
  • Duara R; Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA.
  • Honig LS; Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA.
  • Jones DT; Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami, Florida, USA.
  • Masdeu JC; Taub Institute and Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA.
  • Mendez MF; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
  • Musiek E; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
  • Onyike CU; Nantz National Alzheimer Center, Houston Methodist and Weill Cornell Medicine, Houston, Texas, USA.
  • Riddle M; Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
  • Rogalski E; Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA.
  • Salloway S; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Sha SJ; Department of Neurology, Alpert Medical School, Brown University, Providence, Rhode Island, USA.
  • Turner RS; Department of Psychiatry and Behavioral Sciences, Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
  • Wingo TS; Department of Neurology, Alpert Medical School, Brown University, Providence, Rhode Island, USA.
  • Wolk DA; Department of Neurology & Neurological Sciences, Stanford University, Palo Alto, California, USA.
  • Womack KB; Department of Neurology, Georgetown University, Washington, D.C., USA.
  • Carrillo MC; Department of Neurology and Human Genetics, Emory University School of Medicine, Atlanta, Georgia, USA.
  • Dickerson BC; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Rabinovici GD; Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA.
  • Apostolova LG; Medical & Scientific Relations Division, Alzheimer's Association, Chicago, Illinois, USA.
Alzheimers Dement ; 19 Suppl 9: S115-S125, 2023 11.
Article en En | MEDLINE | ID: mdl-37491668
ABSTRACT

INTRODUCTION:

One goal of the Longitudinal Early Onset Alzheimer's Disease Study (LEADS) is to define the fluid biomarker characteristics of early-onset Alzheimer's disease (EOAD).

METHODS:

Cerebrospinal fluid (CSF) concentrations of Aß1-40, Aß1-42, total tau (tTau), pTau181, VILIP-1, SNAP-25, neurogranin (Ng), neurofilament light chain (NfL), and YKL-40 were measured by immunoassay in 165 LEADS participants. The associations of biomarker concentrations with diagnostic group and standard cognitive tests were evaluated.

RESULTS:

Biomarkers were correlated with one another. Levels of CSF Aß42/40, pTau181, tTau, SNAP-25, and Ng in EOAD differed significantly from cognitively normal and early-onset non-AD dementia; NfL, YKL-40, and VILIP-1 did not. Across groups, all biomarkers except SNAP-25 were correlated with cognition. Within the EOAD group, Aß42/40, NfL, Ng, and SNAP-25 were correlated with at least one cognitive measure.

DISCUSSION:

This study provides a comprehensive analysis of CSF biomarkers in sporadic EOAD that can inform EOAD clinical trial design.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Alzheimers Dement Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Alzheimers Dement Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos