The future of incretins in the treatment of obesity and non-alcoholic fatty liver disease.
Diabetologia
; 66(10): 1846-1858, 2023 10.
Article
en En
| MEDLINE
| ID: mdl-37498367
ABSTRACT
In the last few decades, glucagon-like peptide-1 receptor (GLP-1R) agonists have changed current guidelines and improved outcomes for individuals with type 2 diabetes. However, the dual glucose-dependent insulinotropic polypeptide receptor (GIPR)/GLP-1R agonist, tirzepatide, has demonstrated superior efficacy regarding improvements in HbA1c and body weight in people with type 2 diabetes. This has led to increasing scientific interest in incretin hormones and incretin interactions, and several compounds based on dual- and multi-agonists are now being investigated for the treatment of metabolic diseases. Herein, we highlight the key scientific advances in utilising incretins for the treatment of obesity and, potentially, non-alcoholic fatty liver disease (NAFLD). The development of multi-agonists with multi-organ targets may alter the natural history of these diseases.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Diabetes Mellitus Tipo 2
/
Enfermedad del Hígado Graso no Alcohólico
Tipo de estudio:
Guideline
Límite:
Humans
Idioma:
En
Revista:
Diabetologia
Año:
2023
Tipo del documento:
Article
País de afiliación:
Dinamarca