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HLA Genotype and Probiotics Modify the Association Between Timing of Solid Food Introduction and Islet Autoimmunity in the TEDDY Study.
Uusitalo, Ulla; Mramba, Lazarus K; Aronsson, Carin Andrén; Vehik, Kendra; Yang, Jimin; Hummel, Sandra; Lernmark, Åke; Rewers, Marian; Hagopian, William; McIndoe, Richard; Toppari, Jorma; Ziegler, Anette-G; Akolkar, Beena; Krischer, Jeffrey P; Virtanen, Suvi M; Norris, Jill M.
Afiliación
  • Uusitalo U; Health Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL.
  • Mramba LK; Health Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL.
  • Aronsson CA; Department of Clinical Sciences, Lund University Clinical Research Center, Skåne University Hospital, Malmö, Sweden.
  • Vehik K; Health Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL.
  • Yang J; Health Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL.
  • Hummel S; Institute of Diabetes Research, Helmholtz Zentrum München and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München and Forschergruppe Diabetes e.V., Munich, Germany.
  • Lernmark Å; Department of Clinical Sciences, Lund University Clinical Research Center, Skåne University Hospital, Malmö, Sweden.
  • Rewers M; Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Aurora, CO.
  • Hagopian W; Pacific Northwest Diabetes Research Institute, Seattle, WA.
  • McIndoe R; Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, Augusta, GA.
  • Toppari J; Research Center for Integrative Physiology and Pharmacology, Institute of Biomedicine, and Center for Population Health Research, University of Turku, Turku, Finland.
  • Ziegler AG; Department of Pediatrics, Turku University Hospital, Turku, Finland.
  • Akolkar B; Institute of Diabetes Research, Helmholtz Zentrum München and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München and Forschergruppe Diabetes e.V., Munich, Germany.
  • Krischer JP; National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
  • Virtanen SM; Health Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL.
  • Norris JM; Finnish Institute for Health and Welfare, Health and Welfare Promotion Unit, Helsinki, Finland.
Diabetes Care ; 46(10): 1839-1847, 2023 10 01.
Article en En | MEDLINE | ID: mdl-37579501
OBJECTIVE: To study the interaction among HLA genotype, early probiotic exposure, and timing of complementary foods in relation to risk of islet autoimmunity (IA). RESEARCH DESIGN AND METHODS: The Environmental Determinants of Diabetes in the Young (TEDDY) study prospectively follows 8,676 children with increased genetic risk of type 1 diabetes. We used a Cox proportional hazards regression model adjusting for potential confounders to study early feeding and the risk of IA in a sample of 7,770 children. RESULTS: Any solid food introduced early (<6 months) was associated with increased risk of IA if the child had the HLA DR3/4 genotype and no probiotic exposure during the 1st year of life. Rice introduced at 4-5.9 months compared with later in the U.S. was associated with an increased risk of IA. CONCLUSIONS: Timing of solid food introduction, including rice, may be associated with IA in children with the HLA DR3/4 genotype not exposed to probiotics. The microbiome composition under these exposure combinations requires further study.
Asunto(s)

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Islotes Pancreáticos / Diabetes Mellitus Tipo 1 Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans / Infant Idioma: En Revista: Diabetes Care Año: 2023 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Islotes Pancreáticos / Diabetes Mellitus Tipo 1 Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans / Infant Idioma: En Revista: Diabetes Care Año: 2023 Tipo del documento: Article