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Characterizing the phenotypic and genetic changes of pre-epidemic HIV-2 group F virus following serial passage in humanized mice.
Curlin, James Z; Schmitt, Kimberly; Remling-Mulder, Leila; Tibbitts, Corina Valencia; O'Connor, Shelby; Marx, Preston; Akkina, Ramesh.
Afiliación
  • Curlin JZ; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.
  • Schmitt K; ADEAR Training Program, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
  • Remling-Mulder L; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.
  • Tibbitts CV; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.
  • O'Connor S; Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
  • Marx P; Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
  • Akkina R; Department of Tropical Medicine, School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA.
J Med Primatol ; 52(5): 290-293, 2023 10.
Article en En | MEDLINE | ID: mdl-37658590
HIV-2 Group F virus with an origin in NHPs was isolated from only two individuals. Two serial passages in hu-mice showed increased viral loads, CD4+ T cell decline and nonsynonymous genetic changes showing its capacity for further evolution, and spread in the human.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: VIH-2 Límite: Animals / Humans Idioma: En Revista: J Med Primatol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: VIH-2 Límite: Animals / Humans Idioma: En Revista: J Med Primatol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos