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Mn(OAc)3-Promoted Sulfonation-ipso-Cyclization Cascade via the SO3- Radical: The Synthesis of Spirocyclic Sulfonates.
Zhang, Yan; Han, Bingxu; Gu, Xin; Wang, Kaixuan; Liang, Shuai.
Afiliación
  • Zhang Y; Department of Medicinal Chemistry, School of Pharmacy, Qingdao University Medical College, No.1 Ningde Road, 266071 Qingdao, China.
  • Han B; Department of Medicinal Chemistry, School of Pharmacy, Qingdao University Medical College, No.1 Ningde Road, 266071 Qingdao, China.
  • Gu X; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu 610041, China.
  • Wang K; Department of Medicinal Chemistry, School of Pharmacy, Qingdao University Medical College, No.1 Ningde Road, 266071 Qingdao, China.
  • Liang S; Department of Medicinal Chemistry, School of Pharmacy, Qingdao University Medical College, No.1 Ningde Road, 266071 Qingdao, China.
J Org Chem ; 88(19): 14140-14155, 2023 Oct 06.
Article en En | MEDLINE | ID: mdl-37718492
ABSTRACT
A radical sulfonation-ipso-cyclization cascade promoted by Mn(OAc)3·2H2O using functionalized alkynes or alkenes and potassium metabisulfite (K2S2O5) is reported. A total of 30 spirocyclic sulfonates were synthesized under mild conditions. We also demonstrate a modular synthesis approach in multiple steps for the preparation of various azaspiro[4,5]-trienone-based sulfonamides and sulfonate esters.
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: J Org Chem Año: 2023 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: J Org Chem Año: 2023 Tipo del documento: Article País de afiliación: China