Human macrophage migration inhibition factor: evidence for subunit structure.
Science
; 205(4403): 300-1, 1979 Jul 20.
Article
en En
| MEDLINE
| ID: mdl-377487
ABSTRACT
Macrophage migration inhibition factor (MIF) derived from human lymphoid cell lines was found to lose biologic activity on dialysis. Although activity was not recovered in the dialyzate, mixing experiments demonstrated that the components in the retentate and dialyzate could reassociate to restore activity. The fragment of larger molecular weight (less than 10,000) could inhibit the activity of intact MIF, whereas the smaller molecular weight fragment (5,000 to 10,000) could not. These findings suggest that human MIF is composed of at least two noncovalently linked subunits. In analogy to the situation for certain bacterial toxins, one of these may represent an attachment piece for a target cell membrane receptor.
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Banco de datos:
MEDLINE
Asunto principal:
Factores Inhibidores de la Migración de Macrófagos
Límite:
Humans
Idioma:
En
Revista:
Science
Año:
1979
Tipo del documento:
Article